New Model Predicts Heart Failure Risk in Healthy Adults 09/09/26
Welcome to Cardiology Today â Recorded September 09, 2026. This episode summarizes 5 key cardiology studies on topics like L. D. L. cholesterol and risk estimation. Key takeaway: New Model Predicts Heart Failure Risk in Healthy Adults.
Article Links:
Article 1: Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry. (Circulation)
Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. (European heart journal)
Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. (European heart journal)
Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. (European heart journal)
Article 5: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. (European heart journal)
Full episode page: https://podcast.explainheart.com/podcast/new-model-predicts-heart-failure-risk-in-healthy-adults-09-09-26/
đ Featured Articles
Article 1: Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42360276
Summary: Undertreatment and delayed treatment of aortic stenosis are common, and these issues are associated with increased mortality. The American Heart Association Target: A. S. registry is the first national registry specifically established to provide data and evaluate quality in upstream care processes for patients with aortic stenosis. It includes randomly selected patients from 58 sites with moderate or severe aortic stenosis. This registry directly addresses existing quality gaps in aortic stenosis management by tracking critical aspects of patient care.
Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810961
Summary: Patients with established atherosclerotic cardiovascular disease are at high risk for developing heart failure, and current guideline-recommended models do not include incident heart failure in their risk assessment. This study developed and externally validated the S. M. A. R. T. two-H. F. model to predict incident heart failure specifically in patients with atherosclerotic cardiovascular disease. The S. M. A. R. T. two-H. F. model was developed using data from 7698 individuals with established atherosclerotic cardiovascular disease, including coronary, cerebrovascular, peripheral artery disease, or abdominal aortic aneurysm. This model provides a new tool to identify high-risk individuals for incident heart failure, enabling targeted preventative interventions.
Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810943
Summary: Heart failure presents a significant and growing public health challenge. This study developed and validated S. C. O. R. E. two-H. F., a model for heart failure risk estimation in European adults over 40 years without previous cardiovascular disease. The sex-specific, competing risk-adjusted S. C. O. R. E. two-H. F. models were derived from 611778 individuals across 25 prospective cohorts in 14 countries, observing 21818 incident heart failure events. The model includes age, smoking status, systolic blood pressure, antihypertensive treatment, type two diabetes, and body mass index as predictive factors.
Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810940
Summary: Heart failure with preserved ejection fraction constitutes a heterogeneous disease with a rising incidence and varying prognosis. This study developed and validated the L. I. F. E. hyphen Preserved model for predicting individual short-term and lifetime risk for heart failure hospitalization or cardiovascular death. The L. I. F. E. hyphen Preserved model specifically addresses the need for accurate risk prediction in patients with heart failure with preserved ejection fraction. This new model identifies high-risk individuals within this population, potentially guiding more effective preventive treatment strategies.
Article 5: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721439
Summary: Lipoprotein(a) and L. D. L. cholesterol are causally linked to aortic valve calcium and aortic stenosis. Lipoprotein(a) possesses anti-fibrinolytic properties, suggesting aspirin could potentially reduce cardiovascular disease risk in individuals with high lipoprotein(a) levels. This observational study included up to 6598 participants from the Multi-Ethnic Study of Atherosclerosis. The investigation characterized the relationship between aspirin use and incident aortic valve calcium and aortic stenosis across different lipoprotein(a) and L. D. L. cholesterol levels.
đ Transcript
Today’s date is September 09, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry. Undertreatment and delayed treatment of aortic stenosis are common, and these issues are associated with increased mortality. The American Heart Association Target: A. S. registry is the first national registry specifically established to provide data and evaluate quality in upstream care processes for patients with aortic stenosis. It includes randomly selected patients from 58 sites with moderate or severe aortic stenosis. This registry directly addresses existing quality gaps in aortic stenosis management by tracking critical aspects of patient care.
Article number two. Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. Patients with established atherosclerotic cardiovascular disease are at high risk for developing heart failure, and current guideline-recommended models do not include incident heart failure in their risk assessment. This study developed and externally validated the S. M. A. R. T. two-H. F. model to predict incident heart failure specifically in patients with atherosclerotic cardiovascular disease. The S. M. A. R. T. two-H. F. model was developed using data from 7698 individuals with established atherosclerotic cardiovascular disease, including coronary, cerebrovascular, peripheral artery disease, or abdominal aortic aneurysm. This model provides a new tool to identify high-risk individuals for incident heart failure, enabling targeted preventative interventions.
Article number three. Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. Heart failure presents a significant and growing public health challenge. This study developed and validated S. C. O. R. E. two-H. F., a model for heart failure risk estimation in European adults over 40 years without previous cardiovascular disease. The sex-specific, competing risk-adjusted S. C. O. R. E. two-H. F. models were derived from 611778 individuals across 25 prospective cohorts in 14 countries, observing 21818 incident heart failure events. The model includes age, smoking status, systolic blood pressure, antihypertensive treatment, type two diabetes, and body mass index as predictive factors.
Article number four. Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. Heart failure with preserved ejection fraction constitutes a heterogeneous disease with a rising incidence and varying prognosis. This study developed and validated the L. I. F. E. hyphen Preserved model for predicting individual short-term and lifetime risk for heart failure hospitalization or cardiovascular death. The L. I. F. E. hyphen Preserved model specifically addresses the need for accurate risk prediction in patients with heart failure with preserved ejection fraction. This new model identifies high-risk individuals within this population, potentially guiding more effective preventive treatment strategies.
Article number five. Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. Lipoprotein(a) and L. D. L. cholesterol are causally linked to aortic valve calcium and aortic stenosis. Lipoprotein(a) possesses anti-fibrinolytic properties, suggesting aspirin could potentially reduce cardiovascular disease risk in individuals with high lipoprotein(a) levels. This observational study included up to 6598 participants from the Multi-Ethnic Study of Atherosclerosis. The investigation characterized the relationship between aspirin use and incident aortic valve calcium and aortic stenosis across different lipoprotein(a) and L. D. L. cholesterol levels.
Thank you for listening. Don’t forget to subscribe.
đ Keywords
L. D. L. cholesterol, risk estimation, mortality, risk prediction, S. C. O. R. E. two-H. F., lipoprotein(a), delayed treatment, heart failure, aortic valve calcium, incident heart failure, cardiovascular disease prevention, H. F. pEF, aortic stenosis, risk prediction model, calcific aortic valve disease, European adults, aspirin, quality of care, cardiovascular death, L. I. F. E. hyphen Preserved model, A. H. A. Target: A. S. registry, S. M. A. R. T. two-H. F., atherosclerotic cardiovascular disease, heart failure hospitalization, heart failure with preserved ejection fraction.
âšī¸ About
Concise summaries of cardiovascular research for professionals.
Subscribe âĸ Share âĸ Follow