Systemic RV Impacts TGA Quality of Life 09/18/25
Welcome to Cardiology Today â Recorded September 18, 2025. This episode summarizes 5 key cardiology studies on topics like aortic valve stenosis and quality of life. Key takeaway: Systemic RV Impacts TGA Quality of Life.
Article Links:
Article 1: Quality of Life in Adults with Transposition of the Great Arteries with a Systemic Right or Left Ventricle. (The Canadian journal of cardiology)
Article 2: Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study. (International journal of cardiology)
Article 3: Cardiovascular comorbidities predict mortality in acute pancreatitis. (International journal of cardiology)
Article 4: REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study. (International journal of cardiology)
Article 5: Loop diuretics, heart failure diagnosis and outcome in primary care. (International journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/systemic-rv-impacts-tga-quality-of-life-09-18-25/
đ Featured Articles
Article 1: Quality of Life in Adults with Transposition of the Great Arteries with a Systemic Right or Left Ventricle.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40962221
Summary: This study evaluated quality of life in adults with transposition of the great arteries, including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries, by comparing patients with a systemic right ventricle and those with a systemic left ventricle. The cross-sectional analysis, part of the APPROACH-IS II study, found that overall quality of life was similar between the two groups. However, patients with a systemic right ventricle exhibited lower physical composite scores, indicating poorer physical health compared to those with a systemic left ventricle.
Article 2: Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40409498
Summary: This study evaluated the predictive value of coronary lesion functional assessment using optical coherence tomography (OCT) derived optical flow ratio (OFR). The study found that an abnormal optical flow ratio, indicating functional significance of a coronary lesion, was associated with an increased risk of major adverse cardiac events. Furthermore, combining optical flow ratio with plaque morphology improved risk stratification for adverse cardiac events.
Article 3: Cardiovascular comorbidities predict mortality in acute pancreatitis.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40403851
Summary: This study investigated the association between cardiovascular comorbidities and mortality in patients hospitalized with acute pancreatitis. Using German nationwide inpatient statistics from 2005 to 2019, the study revealed that pre-existing cardiovascular conditions significantly increased in-hospital mortality in patients with acute pancreatitis. These findings underscore the importance of considering cardiovascular comorbidities when assessing risk and managing patients with acute pancreatitis.
Article 4: REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393632
Summary: The REVALVE study is a prospective, open-label registry designed to evaluate the feasibility and outcomes of redo transcatheter aortic valve implantation (TAVI) for bioprosthetic valve failure. Enrolling 300 patients across multiple centers in Europe and the Middle East, this study will assess the safety and efficacy of redo transcatheter aortic valve implantation, providing crucial data on this increasingly relevant treatment strategy. The primary endpoint will assess the composite of all-cause mortality, stroke, or rehospitalization for valve-related symptoms at one year.
Article 5: Loop diuretics, heart failure diagnosis and outcome in primary care.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40393631
Summary: This study examined heart failure assessment, diagnosis, and outcomes following loop diuretic prescription in primary care settings. Analyzing data from the Clinical Practice Research Datalink in the United Kingdom, the study revealed that a substantial proportion of patients prescribed loop diuretics were not assessed for heart failure prior to or after initiation. Furthermore, the study showed that patients who received heart failure assessment had better outcomes compared to those who did not, highlighting the importance of appropriate assessment and diagnosis in patients receiving loop diuretics.
đ Transcript
Today’s date is September 18, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Quality of Life in Adults with Transposition of the Great Arteries with a Systemic Right or Left Ventricle. This study evaluated quality of life in adults with transposition of the great arteries, including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries, by comparing patients with a systemic right ventricle and those with a systemic left ventricle. The cross-sectional analysis, part of the APPROACH-IS II study, found that overall quality of life was similar between the two groups. However, patients with a systemic right ventricle exhibited lower physical composite scores, indicating poorer physical health compared to those with a systemic left ventricle.
Article number two. Predictive value of coronary lesion functional assessment using an OCT computational algorithm in the CLIMA study. This study evaluated the predictive value of coronary lesion functional assessment using optical coherence tomography (OCT) derived optical flow ratio (OFR). The study found that an abnormal optical flow ratio, indicating functional significance of a coronary lesion, was associated with an increased risk of major adverse cardiac events. Furthermore, combining optical flow ratio with plaque morphology improved risk stratification for adverse cardiac events.
Article number three. Cardiovascular comorbidities predict mortality in acute pancreatitis. This study investigated the association between cardiovascular comorbidities and mortality in patients hospitalized with acute pancreatitis. Using German nationwide inpatient statistics from 2005 to 2019, the study revealed that pre-existing cardiovascular conditions significantly increased in-hospital mortality in patients with acute pancreatitis. These findings underscore the importance of considering cardiovascular comorbidities when assessing risk and managing patients with acute pancreatitis.
Article number four. REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study. The REVALVE study is a prospective, open-label registry designed to evaluate the feasibility and outcomes of redo transcatheter aortic valve implantation (TAVI) for bioprosthetic valve failure. Enrolling 300 patients across multiple centers in Europe and the Middle East, this study will assess the safety and efficacy of redo transcatheter aortic valve implantation, providing crucial data on this increasingly relevant treatment strategy. The primary endpoint will assess the composite of all-cause mortality, stroke, or rehospitalization for valve-related symptoms at one year.
Article number five. Loop diuretics, heart failure diagnosis and outcome in primary care. This study examined heart failure assessment, diagnosis, and outcomes following loop diuretic prescription in primary care settings. Analyzing data from the Clinical Practice Research Datalink in the United Kingdom, the study revealed that a substantial proportion of patients prescribed loop diuretics were not assessed for heart failure prior to or after initiation. Furthermore, the study showed that patients who received heart failure assessment had better outcomes compared to those who did not, highlighting the importance of appropriate assessment and diagnosis in patients receiving loop diuretics.
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đ Keywords
aortic valve stenosis, quality of life, loop diuretics, heart failure, redo transcatheter aortic valve implantation, bioprosthetic valve failure, plaque morphology, mortality, cardiovascular comorbidities, optical coherence tomography, transcatheter aortic valve implantation, optical flow ratio, transposition of the great arteries, congenital heart disease, natriuretic peptide, echocardiography, systemic right ventricle, primary care, coronary artery disease, fractional flow reserve, acute pancreatitis, in-hospital mortality.
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Concise summaries of cardiovascular research for professionals.
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