Sirolimus Balloon Challenges Paclitaxel Mortality 02/19/26
Welcome to Cardiology Today â Recorded February 19, 2026. This episode summarizes 5 key cardiology studies on topics like mind-body exercise and older adults. Key takeaway: Sirolimus Balloon Challenges Paclitaxel Mortality.
Article Links:
Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. (Journal of the American College of Cardiology)
Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. (Journal of the American College of Cardiology)
Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. (Journal of the American College of Cardiology)
Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. (Journal of the American College of Cardiology)
Article 5: Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. (Journal of the American College of Cardiology)
Full episode page: https://podcast.explainheart.com/podcast/sirolimus-balloon-challenges-paclitaxel-mortality-02-19-26/
đ Featured Articles
Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706076
Summary: Paclitaxel-coated balloon angioplasty effectively treats femoropopliteal artery disease; however, an increased mortality risk associated with it remains unresolved. Sirolimus-coated balloon angioplasty offers an alternative antiproliferative drug approach for these interventions. The SIRONA randomized noninferiority trial evaluated sirolimus-coated balloon angioplasty against paclitaxel-coated balloon angioplasty. This comparison determines if sirolimus-coated balloons achieve noninferior primary vessel patency and clinical efficacy with an improved safety profile.
Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706075
Summary: Achieving sustained blood pressure lowering with traditional lifestyle guidance and exercise presents a challenge for individuals with high-normal blood pressure. Baduanjin, a traditional Chinese mind-body exercise, serves as a non-pharmacological therapeutic approach under investigation for this population. A multicenter, open-label, blinded-outcome randomized controlled trial assessed Baduanjin’s short-term impact on ambulatory blood pressure and its long-term effects. This study evaluated participants aged 40 years or older who presented with systolic blood pressure of 130 to 139 mmHg or diastolic blood pressure of 85 mmHg or higher.
Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706074
Summary: M. 2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Intensifying wildfires in a warming climate result in prolonged exposure to smoke-derived fine particulate matter (P. M. 2.5), which poses significant health risks. The cardiovascular impacts of long-term cumulative exposure to wildfire smoke P. M. 2.5, particularly in older adults, represent an area of critical clinical investigation. This population-based cohort study analyzed associations between long-term cumulative exposure to wildfire smoke P. M. 2.5 and first cardiovascular disease hospitalizations. The research focused on U.S. Medicare beneficiaries, examining the effects on cardiovascular health in this vulnerable population.
Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706073
Summary: R. With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Recurrent mitral regurgitation degree serves as a key indicator for the quality of mitral valve repair for degenerative mitral regurgitation. This multicenter study evaluated 2-year survival and mitral regurgitation recurrence following mitral valve repair in patients with degenerative mitral regurgitation and moderate or less concomitant tricuspid regurgitation. The research utilized echocardiographic core laboratory-adjudicated data from a cohort of patients who underwent repair between 2016 and 2018. This analysis established long-term outcomes of mitral valve repair in this specific patient group.
Article 5: Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41532932
Summary: Breast cancer chemotherapy elevates cardiovascular risk, with a notable impact on postmenopausal women. While vascular damage, endothelial dysfunction, and oxidative stress are implicated, the precise role of menopausal status in these vascular mechanisms remains unknown. This study investigated the potential protective role of estrogens in premenopausal women against neoadjuvant chemotherapy-induced endothelial dysfunction, specifically focusing on the vascular effects of docetaxel. The research provides insights into how menopausal status influences vascular changes from cancer therapy.
đ Transcript
Today’s date is February 19, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. Paclitaxel-coated balloon angioplasty effectively treats femoropopliteal artery disease; however, an increased mortality risk associated with it remains unresolved. Sirolimus-coated balloon angioplasty offers an alternative antiproliferative drug approach for these interventions. The SIRONA randomized noninferiority trial evaluated sirolimus-coated balloon angioplasty against paclitaxel-coated balloon angioplasty. This comparison determines if sirolimus-coated balloons achieve noninferior primary vessel patency and clinical efficacy with an improved safety profile.
Article number two. Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. Achieving sustained blood pressure lowering with traditional lifestyle guidance and exercise presents a challenge for individuals with high-normal blood pressure. Baduanjin, a traditional Chinese mind-body exercise, serves as a non-pharmacological therapeutic approach under investigation for this population. A multicenter, open-label, blinded-outcome randomized controlled trial assessed Baduanjin’s short-term impact on ambulatory blood pressure and its long-term effects. This study evaluated participants aged 40 years or older who presented with systolic blood pressure of 130 to 139 mmHg or diastolic blood pressure of 85 mmHg or higher.
Article number three. Impact of Long-Term Cumulative Exposure to Wildfire Smoke P. M. 2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Intensifying wildfires in a warming climate result in prolonged exposure to smoke-derived fine particulate matter (P. M. 2.5), which poses significant health risks. The cardiovascular impacts of long-term cumulative exposure to wildfire smoke P. M. 2.5, particularly in older adults, represent an area of critical clinical investigation. This population-based cohort study analyzed associations between long-term cumulative exposure to wildfire smoke P. M. 2.5 and first cardiovascular disease hospitalizations. The research focused on U.S. Medicare beneficiaries, examining the effects on cardiovascular health in this vulnerable population.
Article number four. Mitral Valve Repair for Degenerative M. R. With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Recurrent mitral regurgitation degree serves as a key indicator for the quality of mitral valve repair for degenerative mitral regurgitation. This multicenter study evaluated 2-year survival and mitral regurgitation recurrence following mitral valve repair in patients with degenerative mitral regurgitation and moderate or less concomitant tricuspid regurgitation. The research utilized echocardiographic core laboratory-adjudicated data from a cohort of patients who underwent repair between 2016 and 2018. This analysis established long-term outcomes of mitral valve repair in this specific patient group.
Article number five. Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. Breast cancer chemotherapy elevates cardiovascular risk, with a notable impact on postmenopausal women. While vascular damage, endothelial dysfunction, and oxidative stress are implicated, the precise role of menopausal status in these vascular mechanisms remains unknown. This study investigated the potential protective role of estrogens in premenopausal women against neoadjuvant chemotherapy-induced endothelial dysfunction, specifically focusing on the vascular effects of docetaxel. The research provides insights into how menopausal status influences vascular changes from cancer therapy.
Thank you for listening. Don’t forget to subscribe.
đ Keywords
mind-body exercise, older adults, angioplasty, menopausal status, fine particulate matter, breast cancer, cardiovascular disease, cardiovascular risk, paclitaxel-coated balloon, femoropopliteal artery disease, Baduanjin, chemotherapy, hypertension prevention, high-normal blood pressure, hospital admissions, peripheral artery disease, endothelial dysfunction, mitral regurgitation recurrence, docetaxel, vascular dysfunction, echocardiography, degenerative mitral regurgitation, mitral valve repair, blood pressure lowering, tricuspid regurgitation, cardiac surgery, Medicare beneficiaries, sirolimus-coated balloon, wildfire smoke.
âšī¸ About
Concise summaries of cardiovascular research for professionals.
Subscribe âĸ Share âĸ Follow