Sick Sinus Syndrome Raises Stroke Risk in Low-Risk A. F. 11/30/25
Welcome to Cardiology Today â Recorded November 30, 2025. This episode summarizes 5 key cardiology studies on topics like alloresponse and Pulmonary Vein Isolation. Key takeaway: Sick Sinus Syndrome Raises Stroke Risk in Low-Risk A. F..
Article Links:
Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score. (Heart rhythm)
Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. (Heart rhythm)
Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions. (Heart rhythm)
Article 5: Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long QT Syndrome. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/sick-sinus-syndrome-raises-stroke-risk-in-low-risk-a-f-11-30-25/
đ Featured Articles
Article 1: Donor MHC-specific IgE augments the T and B cell alloresponse in a CD23-dependent manner.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317870
Summary: H. C.-specific IgE augments the T and B cell alloresponse in a C. D. 23-dependent manner. Donor Major Histocompatibility Complex-specific Immunoglobulin E augments both T cell and B cell alloresponses in a C. D. 23-dependent manner. This mechanism indicates that Immunoglobulin E, in addition to its known roles in allergic hypersensitivity, contributes to immune activation relevant to transplant rejection. The presence of donor Major Histocompatibility Complex-specific Immunoglobulin E has been observed in murine transplant models and in human kidney transplant recipients. These findings illuminate a previously unrecognized role for Immunoglobulin E in modulating the alloimmune response, suggesting it influences transplant outcomes.
Article 2: Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low CHA2DS2-VASC Score.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317944
Summary: H. A. 2. D. S. 2. -V. A. S. C. Score. Sick Sinus Syndrome elevates stroke risk specifically in patients with Atrial Fibrillation who have a low C. H. A. 2. D. S. 2. -V. A. S. C. score. This finding indicates that concomitant Sick Sinus Syndrome acts as an independent risk factor for incident ischemic stroke, even in patients considered to be at lower risk by conventional scoring systems. The study, which analyzed a cohort of 24960 patients, suggests that clinicians should consider the presence of Sick Sinus Syndrome when assessing stroke risk in Atrial Fibrillation patients. Therefore, Sick Sinus Syndrome requires careful consideration in comprehensive stroke prevention strategies for this patient population.
Article 3: The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317943
Summary: Pulsed-field Ablation for Pulmonary Vein Isolation demonstrates a superior safety profile regarding gastric motility compared to Radiofrequency Ablation. Radiofrequency Ablation for Pulmonary Vein Isolation was observed to impair gastric motility due to collateral thermal injury. In contrast, Pulsed-field Ablation, being a nonthermal modality, preferentially affected cardiomyocytes and preserved gastric motility in patients with Atrial Fibrillation. This indicates that Pulsed-field Ablation offers a significant advantage in reducing the risk of gastric motility impairment during Pulmonary Vein Isolation procedures.
Article 4: New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317942
Summary: A novel technique effectively achieves total Mitral Isthmus Block by successfully targeting masked epicardial conductions. The study identified that epicardial conduction played a key role in peri-mitral atrial tachycardia recurrence, which was subsequently addressed by this approach. Targeting these previously masked epicardial pathways with Radiofrequency Ablation proved feasible and instrumental in achieving complete and durable Mitral Isthmus Block. This new method provides a crucial advancement for patients undergoing ablation for persistent Atrial Fibrillation.
Article 5: Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long QT Syndrome.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41317941
Summary: T. Syndrome. Non-penetrant Long Q. T. Syndrome, defined as the absence of objective electrocardiographic or cardiac evidence of abnormal cardiac repolarization despite a positive genotype, represents a distinct clinical entity. This condition highlights that not all individuals with a Long Q. T. Syndrome genotype manifest the typical prolongation of the Q. T. interval or associated clinical events like syncope or sudden cardiac arrest. Understanding the prevalence, spectrum, and long-term outcomes of non-penetrant Long Q. T. Syndrome is crucial for genetic counseling and personalized risk stratification. It offers a critical distinction within the broader Long Q. T. Syndrome population for clinical management.
đ Transcript
Today’s date is November 30, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Donor M. H. C.-specific IgE augments the T and B cell alloresponse in a C. D. 23-dependent manner. Donor Major Histocompatibility Complex-specific Immunoglobulin E augments both T cell and B cell alloresponses in a C. D. 23-dependent manner. This mechanism indicates that Immunoglobulin E, in addition to its known roles in allergic hypersensitivity, contributes to immune activation relevant to transplant rejection. The presence of donor Major Histocompatibility Complex-specific Immunoglobulin E has been observed in murine transplant models and in human kidney transplant recipients. These findings illuminate a previously unrecognized role for Immunoglobulin E in modulating the alloimmune response, suggesting it influences transplant outcomes.
Article number two. Sick Sinus Syndrome Elevates Stroke Risk in Atrial Fibrillation Patients with Low C. H. A. 2. D. S. 2. -V. A. S. C. Score. Sick Sinus Syndrome elevates stroke risk specifically in patients with Atrial Fibrillation who have a low C. H. A. 2. D. S. 2. -V. A. S. C. score. This finding indicates that concomitant Sick Sinus Syndrome acts as an independent risk factor for incident ischemic stroke, even in patients considered to be at lower risk by conventional scoring systems. The study, which analyzed a cohort of 24960 patients, suggests that clinicians should consider the presence of Sick Sinus Syndrome when assessing stroke risk in Atrial Fibrillation patients. Therefore, Sick Sinus Syndrome requires careful consideration in comprehensive stroke prevention strategies for this patient population.
Article number three. The Effect of Pulmonary Vein Isolation on Gastric Motility: Pulsed-field Ablation vs Radiofrequency. Pulsed-field Ablation for Pulmonary Vein Isolation demonstrates a superior safety profile regarding gastric motility compared to Radiofrequency Ablation. Radiofrequency Ablation for Pulmonary Vein Isolation was observed to impair gastric motility due to collateral thermal injury. In contrast, Pulsed-field Ablation, being a nonthermal modality, preferentially affected cardiomyocytes and preserved gastric motility in patients with Atrial Fibrillation. This indicates that Pulsed-field Ablation offers a significant advantage in reducing the risk of gastric motility impairment during Pulmonary Vein Isolation procedures.
Article number four. New Technique to Achieve Total Mitral Isthmus Block: Targeting Masked Epicardial Conductions. A novel technique effectively achieves total Mitral Isthmus Block by successfully targeting masked epicardial conductions. The study identified that epicardial conduction played a key role in peri-mitral atrial tachycardia recurrence, which was subsequently addressed by this approach. Targeting these previously masked epicardial pathways with Radiofrequency Ablation proved feasible and instrumental in achieving complete and durable Mitral Isthmus Block. This new method provides a crucial advancement for patients undergoing ablation for persistent Atrial Fibrillation.
Article number five. Prevalence, Spectrum and Outcomes in Patients with Non-Penetrant Long Q. T. Syndrome. Non-penetrant Long Q. T. Syndrome, defined as the absence of objective electrocardiographic or cardiac evidence of abnormal cardiac repolarization despite a positive genotype, represents a distinct clinical entity. This condition highlights that not all individuals with a Long Q. T. Syndrome genotype manifest the typical prolongation of the Q. T. interval or associated clinical events like syncope or sudden cardiac arrest. Understanding the prevalence, spectrum, and long-term outcomes of non-penetrant Long Q. T. Syndrome is crucial for genetic counseling and personalized risk stratification. It offers a critical distinction within the broader Long Q. T. Syndrome population for clinical management.
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đ Keywords
alloresponse, Pulmonary Vein Isolation, electrocardiographic abnormality, B cell activation, Mitral Isthmus Block, gastric motility, transplant rejection, sudden cardiac death, T cell activation, Donor M. H. C., genotype positive, persistent Atrial Fibrillation, Radiofrequency Ablation, Immunoglobulin E, stroke risk, non-penetrant, Sick Sinus Syndrome, ischemic stroke, Long Q. T. Syndrome, Pulsed-field Ablation, Atrial Fibrillation, epicardial conduction, C. H. A. 2. D. S. 2. -V. A. S. C. score, atrial tachycardia.
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