S-Wave Loss Predicts Pulsed Field Ablation Durability 01/26/26
Welcome to Cardiology Today – Recorded January 26, 2026. This episode summarizes 5 key cardiology studies on topics like S-wave loss and incident arrhythmia. Key takeaway: S-Wave Loss Predicts Pulsed Field Ablation Durability.
Article Links:
Article 1: Serial Assessment of Cardiac Mitochondrial Function in the Early Phase After Heart Transplantation. (Transplantation)
Article 2: LUNG TRANSPLANTATION AFTER PROLONGED TA-NRP IN COMBINED HEART-LUNG PROCUREMENT FROM CONTROLLED DCD DONORS IN ITALY. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
Article 3: Atrial fibrillation in patients ≤50 years: Clinical characteristics, treatment, risk of ischemic stroke, and outcomes. (Heart rhythm)
Article 4: Closure of Secundum Atrial Septal Defect and Risk of Incident and Recurrent Arrhythmia. (Heart rhythm)
Article 5: Unipolar Voltage Mapping to Predict Lesion Durability During Pulsed Field Ablation. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/s-wave-loss-predicts-pulsed-field-ablation-durability-01-26-26/
📚 Featured Articles
Article 1: Serial Assessment of Cardiac Mitochondrial Function in the Early Phase After Heart Transplantation.
Journal: Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41572446
Summary: Mitochondrial dysfunction is a recognized contributor to cardiac pathology and influences myocardial recovery after heart transplantation. This prospective single-center study involved 45 adult heart transplant recipients. It characterized the changes in cardiac mitochondrial function directly in human myocardial tissue during the early post-transplant period. Understanding these dynamics is crucial for optimizing cardiac recovery and metabolic status.
Article 2: LUNG TRANSPLANTATION AFTER PROLONGED TA-NRP IN COMBINED HEART-LUNG PROCUREMENT FROM CONTROLLED DCD DONORS IN ITALY.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41581668
Summary: Thoraco-abdominal normothermic regional perfusion is an emerging strategy for heart recovery in controlled donation after circulatory death donors. However, its impact on lung graft retrieval is debated, particularly with prolonged durations. In Italy, a mandatory 20-minute stand-off period results in uniquely prolonged thoraco-abdominal normothermic regional perfusion for heart assessment during combined heart-lung procurement. This Italian nationwide experience provides crucial clinical data on lung transplant outcomes following this specific prolonged perfusion strategy.
Article 3: Atrial fibrillation in patients ≤50 years: Clinical characteristics, treatment, risk of ischemic stroke, and outcomes.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41581852
Summary: The incidence of atrial fibrillation in patients aged 18-50 years has increased, yet clinical data for this population is limited. This study characterized the clinical features, treatment patterns, and risk of ischemic stroke in hospitalized young atrial fibrillation patients between 2014 and 2023. Through Cox regression analysis, researchers identified specific risk factors for major adverse cardiac and cerebrovascular events and new-onset ischemic stroke in this cohort. This investigation provides crucial data on the unique clinical presentation and specific risks faced by younger individuals with atrial fibrillation.
Article 4: Closure of Secundum Atrial Septal Defect and Risk of Incident and Recurrent Arrhythmia.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41581850
Summary: Secundum atrial septal defect is associated with substantial morbidity, especially arrhythmias, despite being a simple defect. This Danish nationwide cohort study, spanning from 1977 to 2024, included all diagnosed secundum atrial septal defect patients. The study systematically assessed the risk of both incident and recurrent arrhythmias in relation to atrial septal defect closure status and the timing of intervention. This extensive analysis generated definitive data on the long-term arrhythmic burden after secundum atrial septal defect closure.
Article 5: Unipolar Voltage Mapping to Predict Lesion Durability During Pulsed Field Ablation.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41581848
Summary: Unipolar electrograms show utility in assessing lesion durability during pulsed field ablation. This study investigated voltages associated with unipolar electrogram changes after pulsed field ablation and evaluated their predictive value for lesion durability. In one group of 10 patients, areas exhibiting a loss of S-wave on unipolar electrograms correlated with core lesion formation. The findings indicate that serial unipolar and bipolar voltage mapping provides objective evidence for lesion creation and durability during pulsed field ablation procedures.
📝 Transcript
Today’s date is January 26, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Serial Assessment of Cardiac Mitochondrial Function in the Early Phase After Heart Transplantation. Mitochondrial dysfunction is a recognized contributor to cardiac pathology and influences myocardial recovery after heart transplantation. This prospective single-center study involved 45 adult heart transplant recipients. It characterized the changes in cardiac mitochondrial function directly in human myocardial tissue during the early post-transplant period. Understanding these dynamics is crucial for optimizing cardiac recovery and metabolic status.
Article number two. LUNG TRANSPLANTATION AFTER PROLONGED TA-NRP IN COMBINED HEART-LUNG PROCUREMENT FROM CONTROLLED DCD DONORS IN ITALY. Thoraco-abdominal normothermic regional perfusion is an emerging strategy for heart recovery in controlled donation after circulatory death donors. However, its impact on lung graft retrieval is debated, particularly with prolonged durations. In Italy, a mandatory 20-minute stand-off period results in uniquely prolonged thoraco-abdominal normothermic regional perfusion for heart assessment during combined heart-lung procurement. This Italian nationwide experience provides crucial clinical data on lung transplant outcomes following this specific prolonged perfusion strategy.
Article number three. Atrial fibrillation in patients ≤50 years: Clinical characteristics, treatment, risk of ischemic stroke, and outcomes. The incidence of atrial fibrillation in patients aged 18-50 years has increased, yet clinical data for this population is limited. This study characterized the clinical features, treatment patterns, and risk of ischemic stroke in hospitalized young atrial fibrillation patients between 2014 and 2023. Through Cox regression analysis, researchers identified specific risk factors for major adverse cardiac and cerebrovascular events and new-onset ischemic stroke in this cohort. This investigation provides crucial data on the unique clinical presentation and specific risks faced by younger individuals with atrial fibrillation.
Article number four. Closure of Secundum Atrial Septal Defect and Risk of Incident and Recurrent Arrhythmia. Secundum atrial septal defect is associated with substantial morbidity, especially arrhythmias, despite being a simple defect. This Danish nationwide cohort study, spanning from 1977 to 2024, included all diagnosed secundum atrial septal defect patients. The study systematically assessed the risk of both incident and recurrent arrhythmias in relation to atrial septal defect closure status and the timing of intervention. This extensive analysis generated definitive data on the long-term arrhythmic burden after secundum atrial septal defect closure.
Article number five. Unipolar Voltage Mapping to Predict Lesion Durability During Pulsed Field Ablation. Unipolar electrograms show utility in assessing lesion durability during pulsed field ablation. This study investigated voltages associated with unipolar electrogram changes after pulsed field ablation and evaluated their predictive value for lesion durability. In one group of 10 patients, areas exhibiting a loss of S-wave on unipolar electrograms correlated with core lesion formation. The findings indicate that serial unipolar and bipolar voltage mapping provides objective evidence for lesion creation and durability during pulsed field ablation procedures.
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🔍 Keywords
S-wave loss, incident arrhythmia, secundum atrial septal defect, arrhythmia, recurrent arrhythmia, heart transplantation, lesion durability, metabolic status, atrial fibrillation, heart-lung procurement, cardiac mitochondrial function, myocardial recovery, voltage mapping, risk factors, lung transplantation, graft retrieval, young patients, atrial septal defect closure, controlled donation after circulatory death, pulsed field ablation, ischemic stroke, major adverse cardiac and cerebrovascular events, unipolar electrograms, thoraco-abdominal normothermic regional perfusion.
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Concise summaries of cardiovascular research for professionals.
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