Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25

Cardiology Today

Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25

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Welcome to Cardiology Today – Recorded October 03, 2025. This episode summarizes 5 key cardiology studies on topics like gene-edited pigs and H.C.N.4. Key takeaway: Osimertinib Arrhythmia: K.C.N.N.1 Link Found.

Article Links:

Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. (Circulation)

Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF. (JACC. Heart failure)

Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. (Heart rhythm)

Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment. (Heart rhythm)

Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. (Heart rhythm)

Full episode page: https://podcast.explainheart.com/podcast/osimertinib-arrhythmia-k-c-n-n-1-link-found-10-03-25/

📚 Featured Articles

Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.

Journal: Circulation

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41036838

Summary: Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.

Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF.

Journal: JACC. Heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41037837

Summary: Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction.

Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia.

Journal: Heart rhythm

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40653133

Summary: Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia.

Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment.

Journal: Heart rhythm

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645436

Summary: Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment.

Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.

Journal: Heart rhythm

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40582687

Summary: Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.

📝 Transcript

🔍 Keywords

gene-edited pigs, H.C.N.4, epidermal growth factor receptor-tyrosine kinase inhibitor, induced pluripotent stem cell-derived cardiomyocytes, incidence, cardiotoxicity, congestion, heart rate modulation, Heart Failure with Preserved Ejection Fraction, echocardiographic imaging, pacing complications, cardiac tamponade, osimertinib, arrhythmia, sinus node, pig-to-human heart transplant, xenotransplantation, action potential duration, transvenous temporary pacing, multimodal phenotyping, xeno-immune response, obesity, cardiac perforation, low cardiac output, I.L.-34, K.C.N.N.1, microRNAs, hemodynamic phenotype, clinical outcomes.

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Concise summaries of cardiovascular research for professionals.

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