LVEF Not Enough: Heart Failure Phenotyping Shift 02/27/26
Welcome to Cardiology Today â Recorded February 27, 2026. This episode summarizes 5 key cardiology studies on topics like left ventricular ejection fraction and clinical outcomes. Key takeaway: LVEF Not Enough: Heart Failure Phenotyping Shift.
Article Links:
Article 1: Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry. (ESC heart failure)
Article 2: Costs and outcomes in Finnish heart failure patients treated with left ventricular assist device or heart transplant. (ESC heart failure)
Article 3: Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis. (Journal of the American Heart Association)
Article 4: Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association. (Journal of the American Heart Association)
Article 5: Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/lvef-not-enough-heart-failure-phenotyping-shift-02-27-26/
đ Featured Articles
Article 1: Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41746839
Summary: The Shock-POL registry, encompassing data from nine Polish cardiology centers, characterized the current management and outcomes of acute myocardial infarction-related cardiogenic shock. This registry evaluated patients hospitalized throughout 2023, identifying parameters of current care for this critical condition. Findings reveal that acute myocardial infarction-related cardiogenic shock carries an overall mortality rate exceeding 50 percent. The study documented clinical practices and patient outcomes in a real-world setting.
Article 2: Costs and outcomes in Finnish heart failure patients treated with left ventricular assist device or heart transplant.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41739853
Summary: This retrospective study provided a real-world comparative analysis of clinical outcomes and healthcare costs for Finnish advanced heart failure patients treated with heart transplantation or left ventricular assist device therapy. The study evaluated 78 patients across three categories: those receiving heart transplantation as a first procedure, and patients undergoing elective or urgent left ventricular assist device implantation. The data characterized the three-year outcomes and associated healthcare expenditures for these significant interventions at Helsinki University Hospital. It established patterns in resource utilization and patient trajectories for these advanced heart failure treatment options.
Article 3: Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744134
Summary: This cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis cohort established the relationship between cigarette smoking and interstitial myocardial fibrosis. The study utilized extracellular volume and native T1 time, measured by cardiac magnetic resonance, as markers for myocardial fibrosis. It characterized sex-specific differences in these associations at a population level. The findings illuminate how smoking impacts myocardial fibrosis, which is critical given its known association with cardiovascular events, heart failure, and death.
Article 4: Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744120
Summary: This Scientific Statement from the American Heart Association establishes a multimodality approach to coronary ischemic testing in pediatric patients. It provides updated recommendations for targeted provocative ischemic testing in children with acquired and congenital coronary issues. The statement synthesizes evidence-based guidelines for conditions such as Kawasaki disease, multisystem inflammatory syndrome in children with coronary aneurysms, and anomalous aortic origin of the coronary arteries. It details the value and application of various ischemic testing modalities to guide clinical practice in pediatric cardiology.
Article 5: Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744116
Summary: This study evaluated the limitations of conventional left ventricular ejection fraction-based heart failure phenotyping, highlighting its weak correlation with outcomes and potential overestimation of systolic function, particularly in elderly women. Researchers assessed sex-specific differences in left ventricular geometry and tested whether geometry-adjusted left ventricular ejection fraction or left ventricular global longitudinal strain improves prognostic performance. The findings challenge the sole reliance on left ventricular ejection fraction as a cornerstone of heart failure phenotyping, indicating a need for more nuanced myocardial assessments. The study demonstrated how alternative metrics like left ventricular global longitudinal strain can offer improved prognostic insights beyond traditional chamber-based measurements.
đ Transcript
Today’s date is February 27, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry. The Shock-POL registry, encompassing data from nine Polish cardiology centers, characterized the current management and outcomes of acute myocardial infarction-related cardiogenic shock. This registry evaluated patients hospitalized throughout 2023, identifying parameters of current care for this critical condition. Findings reveal that acute myocardial infarction-related cardiogenic shock carries an overall mortality rate exceeding 50 percent. The study documented clinical practices and patient outcomes in a real-world setting.
Article number two. Costs and outcomes in Finnish heart failure patients treated with left ventricular assist device or heart transplant. This retrospective study provided a real-world comparative analysis of clinical outcomes and healthcare costs for Finnish advanced heart failure patients treated with heart transplantation or left ventricular assist device therapy. The study evaluated 78 patients across three categories: those receiving heart transplantation as a first procedure, and patients undergoing elective or urgent left ventricular assist device implantation. The data characterized the three-year outcomes and associated healthcare expenditures for these significant interventions at Helsinki University Hospital. It established patterns in resource utilization and patient trajectories for these advanced heart failure treatment options.
Article number three. Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis cohort established the relationship between cigarette smoking and interstitial myocardial fibrosis. The study utilized extracellular volume and native T1 time, measured by cardiac magnetic resonance, as markers for myocardial fibrosis. It characterized sex-specific differences in these associations at a population level. The findings illuminate how smoking impacts myocardial fibrosis, which is critical given its known association with cardiovascular events, heart failure, and death.
Article number four. Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association. This Scientific Statement from the American Heart Association establishes a multimodality approach to coronary ischemic testing in pediatric patients. It provides updated recommendations for targeted provocative ischemic testing in children with acquired and congenital coronary issues. The statement synthesizes evidence-based guidelines for conditions such as Kawasaki disease, multisystem inflammatory syndrome in children with coronary aneurysms, and anomalous aortic origin of the coronary arteries. It details the value and application of various ischemic testing modalities to guide clinical practice in pediatric cardiology.
Article number five. Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium. This study evaluated the limitations of conventional left ventricular ejection fraction-based heart failure phenotyping, highlighting its weak correlation with outcomes and potential overestimation of systolic function, particularly in elderly women. Researchers assessed sex-specific differences in left ventricular geometry and tested whether geometry-adjusted left ventricular ejection fraction or left ventricular global longitudinal strain improves prognostic performance. The findings challenge the sole reliance on left ventricular ejection fraction as a cornerstone of heart failure phenotyping, indicating a need for more nuanced myocardial assessments. The study demonstrated how alternative metrics like left ventricular global longitudinal strain can offer improved prognostic insights beyond traditional chamber-based measurements.
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đ Keywords
left ventricular ejection fraction, clinical outcomes, American Heart Association, left ventricular assist device, myocardial fibrosis, myocardial geometry, sex differences, healthcare costs, registry, coronary ischemic testing, advanced heart failure, left ventricular global longitudinal strain, patient management, acute myocardial infarction, cardiogenic shock, congenital heart disease, Multi-Ethnic Study of Atherosclerosis, cardiac magnetic resonance, heart failure phenotyping, pediatric cardiology, prognosis, cigarette smoking, Kawasaki disease, mortality, heart transplantation.
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Concise summaries of cardiovascular research for professionals.
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