Angina Endotypes: Precision Treatment Advances 11/12/25
Welcome to Cardiology Today â Recorded November 12, 2025. This episode summarizes 5 key cardiology studies on topics like monotherapy and exercise hemodynamics. Key takeaway: Angina Endotypes: Precision Treatment Advances.
Article Links:
Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. (Circulation)
Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. (European heart journal)
Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. (European heart journal)
Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? (European heart journal)
Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study. (Journal of cardiac failure)
Full episode page: https://podcast.explainheart.com/podcast/angina-endotypes-precision-treatment-advances-11-12-25/
đ Featured Articles
Article 1: miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41208706
Summary: This study investigated the mechanisms by which myocardial infarction triggers myelopoiesis and exacerbates disease pathology. Researchers induced myocardial infarction in mice and found that platelet-derived extracellular vesicles containing micro-R. N. A. minus 499 augmented inflammatory cell generation and cardiac remodeling. This discovery indicates that micro-R. N. A. minus 499 from platelet extracellular vesicles plays a critical role in promoting adverse cardiac remodeling and identifies a potential therapeutic target.
Article 2: Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41217874
Summary: This research explored the role of adaptive immune responses in human atherosclerosis progression. Using R. N. A. sequencing and immunohistochemistry on human atherosclerotic plaques, the study revealed that enhanced antigen presentation by macrophages promotes the disease. This finding highlights the critical involvement of macrophage-driven immune responses in atherosclerosis pathology and suggests novel therapeutic strategies targeting this pathway.
Article 3: Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41214896
Summary: This prospective multicenter study aimed to better diagnose and treat angina with non-obstructive coronary arteries, a prevalent myocardial ischemic syndrome. Researchers enrolled consecutive patients undergoing coronary functional testing across nine centers to identify distinct hemodynamic endotypes. The study successfully stratified patients into these endotypes, demonstrating differential responses to specific treatments and thereby establishing a foundation for a precision medicine approach.
Article 4: Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease?
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41211721
Summary: While aspirin has been the traditional cornerstone antiplatelet therapy, the review highlights emerging evidence suggesting P2Y12 inhibitors may be more than just an alternative. The findings suggest that P2Y12 inhibitors may be preferred over aspirin as a single antiplatelet agent, offering a significant therapeutic consideration for clinicians.
Article 5: Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study.
Journal: Journal of cardiac failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41213849
Summary: This multicenter study investigated the clinical significance of moderate to severe tricuspid regurgitation during evaluation for unexplained dyspnea. Researchers assessed 258 patients with exercise heart failure with preserved ejection fraction using exercise right heart catheterization. They found that moderate to severe tricuspid regurgitation was independently associated with worse exercise capacity and adverse five-year clinical outcomes, underscoring its prognostic importance in this patient population.
đ Transcript
Today’s date is November 12, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction. This study investigated the mechanisms by which myocardial infarction triggers myelopoiesis and exacerbates disease pathology. Researchers induced myocardial infarction in mice and found that platelet-derived extracellular vesicles containing micro-R. N. A. minus 499 augmented inflammatory cell generation and cardiac remodeling. This discovery indicates that micro-R. N. A. minus 499 from platelet extracellular vesicles plays a critical role in promoting adverse cardiac remodeling and identifies a potential therapeutic target.
Article number two. Enhanced antigen presentation by macrophages promotes human atherosclerosis progression: therapeutic implications. This research explored the role of adaptive immune responses in human atherosclerosis progression. Using R. N. A. sequencing and immunohistochemistry on human atherosclerotic plaques, the study revealed that enhanced antigen presentation by macrophages promotes the disease. This finding highlights the critical involvement of macrophage-driven immune responses in atherosclerosis pathology and suggests novel therapeutic strategies targeting this pathway.
Article number three. Endotypes of angina with non-obstructive coronary arteries: a prospective multicentre study. This prospective multicenter study aimed to better diagnose and treat angina with non-obstructive coronary arteries, a prevalent myocardial ischemic syndrome. Researchers enrolled consecutive patients undergoing coronary functional testing across nine centers to identify distinct hemodynamic endotypes. The study successfully stratified patients into these endotypes, demonstrating differential responses to specific treatments and thereby establishing a foundation for a precision medicine approach.
Article number four. Aspirin or P2Y12 inhibitor monotherapy in atherosclerotic cardiovascular disease? This review examined the current evidence comparing aspirin and P2Y12 inhibitor monotherapy for the long-term management of atherosclerotic cardiovascular disease. While aspirin has been the traditional cornerstone antiplatelet therapy, the review highlights emerging evidence suggesting P2Y12 inhibitors may be more than just an alternative. The findings suggest that P2Y12 inhibitors may be preferred over aspirin as a single antiplatelet agent, offering a significant therapeutic consideration for clinicians.
Article number five. Association of Moderate to Severe Tricuspid Regurgitation With Exercise Hemodynamics and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: Multicenter Study. This multicenter study investigated the clinical significance of moderate to severe tricuspid regurgitation during evaluation for unexplained dyspnea. Researchers assessed 258 patients with exercise heart failure with preserved ejection fraction using exercise right heart catheterization. They found that moderate to severe tricuspid regurgitation was independently associated with worse exercise capacity and adverse five-year clinical outcomes, underscoring its prognostic importance in this patient population.
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đ Keywords
monotherapy, exercise hemodynamics, adaptive immune response, aspirin, macrophages, atherosclerosis, prognostic indicator, heart failure with preserved ejection fraction, antigen presentation, P2Y12 inhibitors, atherosclerotic cardiovascular disease, platelet-derived extracellular vesicles, endotypes, precision medicine, T cells, myocardial ischemia, coronary functional testing, myelopoiesis, dyspnea, antiplatelet therapy, angina with non-obstructive coronary arteries, myocardial infarction, micro-R. N. A. minus 499, cardiac remodeling, tricuspid regurgitation.
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Concise summaries of cardiovascular research for professionals.
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