Adipose Tissue Drives Heart Failure Pathogenesis 02/08/26
Welcome to Cardiology Today â Recorded February 08, 2026. This episode summarizes 5 key cardiology studies on topics like preeclampsia and maternal-fetal interface. Key takeaway: Adipose Tissue Drives Heart Failure Pathogenesis.
Article Links:
Article 1: Coronary Artery Compliance Modification after Non-Compliant Balloon Angioplasty and Intravascular Lithotripsy. (The American journal of cardiology)
Article 2: Outcomes of High-Risk Pulmonary Embolism Stratified by Clinical Phenotype: Results from Two Specialized Pulmonary Embolism Centres. (The Canadian journal of cardiology)
Article 3: Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction. (Cardiovascular research)
Article 4: SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia. (Hypertension (Dallas, Tex. : 1979))
Article 5: circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension. (Hypertension (Dallas, Tex. : 1979))
Full episode page: https://podcast.explainheart.com/podcast/adipose-tissue-drives-heart-failure-pathogenesis-02-08-26/
đ Featured Articles
Article 1: Coronary Artery Compliance Modification after Non-Compliant Balloon Angioplasty and Intravascular Lithotripsy.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41654158
Summary: Intravascular lithotripsy demonstrates efficacy in treating balloon-crossable calcified coronary lesions. It achieves this by inducing calcium fractures and improving coronary artery compliance. This study evaluates patients with calcified coronary artery lesions from the BENELUX-IVL prospective registry who received intravascular lithotripsy under intravascular ultrasound. The research provides a direct comparison of coronary artery compliance modification between intravascular lithotripsy and non-compliant balloon angioplasty.
Article 2: Outcomes of High-Risk Pulmonary Embolism Stratified by Clinical Phenotype: Results from Two Specialized Pulmonary Embolism Centres.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41653976
Summary: High-risk pulmonary embolism presents with high early mortality and a heterogeneous patient population, ranging from cardiac arrest to obstructive shock or hypotension. Systemic thrombolysis remains the standard of care, but its use is limited by contraindications and bleeding risk. Catheter-directed therapies offer alternatives, though data on their use in high-risk pulmonary embolism is limited. This study characterized the clinical characteristics, management strategies, and outcomes across three distinct high-risk pulmonary embolism clinical phenotypes.
Article 3: Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645491
Summary: Heart failure with preserved ejection fraction (H. F. pEF) phenotypes were induced in male C57BL/6N mice using a high-fat diet combined with NĪ-nitro-l-arginine methyl ester. The study found a causal relationship between adiposity and Heart Failure with Preserved Ejection Fraction pathogenesis. Resection of visceral adipose tissue blunted Heart Failure with Preserved Ejection Fraction phenotypes in mice, while transplantation of visceral adipose tissue exacerbated these phenotypes.
Article 4: SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645896
Summary: Preeclampsia, a severe hypertensive disorder of pregnancy, is associated with low sirtuin 1 (SIRT1) levels in trophoblasts. Single-cell sequencing of systemic sirtuin 1 heterozygous knockout mice revealed abnormal activation of trophoblast retinoic acid receptor responder 2 (RARRES2) and macrophage chemokine-like receptor 1 (CMKLR1) at the maternal-fetal interface. The investigation determined that low sirtuin 1 in trophoblasts increases retinoic acid receptor responder 2 expression, which subsequently affects macrophage polarization. This mechanism clarifies a key pathway in preeclampsia pathogenesis.
Article 5: circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41641542
Summary: A pulmonary hypertension (P. H.)-related circular R. N. A., circMFN2, originating from the mitofusin-2 (MFN2) locus, was identified. This circMFN2 was significantly downregulated in the peripheral blood of patients with P. H. and in the pulmonary arteries of Sugen/hypoxia-induced P. H. mice. The study demonstrated that circMFN2 regulates the insulin-like growth factor two messenger R. N. A. binding protein three (IGF2BP3)-pyruvate dehydrogenase kinase four (PDK4) pathway. This regulation by circMFN2 ameliorates P. H., indicating its role as a potential therapeutic target.
đ Transcript
Today’s date is February 08, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Coronary Artery Compliance Modification after Non-Compliant Balloon Angioplasty and Intravascular Lithotripsy. Intravascular lithotripsy demonstrates efficacy in treating balloon-crossable calcified coronary lesions. It achieves this by inducing calcium fractures and improving coronary artery compliance. This study evaluates patients with calcified coronary artery lesions from the BENELUX-IVL prospective registry who received intravascular lithotripsy under intravascular ultrasound. The research provides a direct comparison of coronary artery compliance modification between intravascular lithotripsy and non-compliant balloon angioplasty.
Article number two. Outcomes of High-Risk Pulmonary Embolism Stratified by Clinical Phenotype: Results from Two Specialized Pulmonary Embolism Centres. High-risk pulmonary embolism presents with high early mortality and a heterogeneous patient population, ranging from cardiac arrest to obstructive shock or hypotension. Systemic thrombolysis remains the standard of care, but its use is limited by contraindications and bleeding risk. Catheter-directed therapies offer alternatives, though data on their use in high-risk pulmonary embolism is limited. This study characterized the clinical characteristics, management strategies, and outcomes across three distinct high-risk pulmonary embolism clinical phenotypes.
Article number three. Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction. Heart failure with preserved ejection fraction (H. F. pEF) phenotypes were induced in male C57BL/6N mice using a high-fat diet combined with NĪ-nitro-l-arginine methyl ester. The study found a causal relationship between adiposity and Heart Failure with Preserved Ejection Fraction pathogenesis. Resection of visceral adipose tissue blunted Heart Failure with Preserved Ejection Fraction phenotypes in mice, while transplantation of visceral adipose tissue exacerbated these phenotypes.
Article number four. SIRT1-NCOR2 Corepressor Modulates Trophoblast-Macrophage Interactions in Preeclampsia. Preeclampsia, a severe hypertensive disorder of pregnancy, is associated with low sirtuin 1 (SIRT1) levels in trophoblasts. Single-cell sequencing of systemic sirtuin 1 heterozygous knockout mice revealed abnormal activation of trophoblast retinoic acid receptor responder 2 (RARRES2) and macrophage chemokine-like receptor 1 (CMKLR1) at the maternal-fetal interface. The investigation determined that low sirtuin 1 in trophoblasts increases retinoic acid receptor responder 2 expression, which subsequently affects macrophage polarization. This mechanism clarifies a key pathway in preeclampsia pathogenesis.
Article number five. circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension. A pulmonary hypertension (P. H.)-related circular R. N. A., circMFN2, originating from the mitofusin-2 (MFN2) locus, was identified. This circMFN2 was significantly downregulated in the peripheral blood of patients with P. H. and in the pulmonary arteries of Sugen/hypoxia-induced P. H. mice. The study demonstrated that circMFN2 regulates the insulin-like growth factor two messenger R. N. A. binding protein three (IGF2BP3)-pyruvate dehydrogenase kinase four (PDK4) pathway. This regulation by circMFN2 ameliorates P. H., indicating its role as a potential therapeutic target.
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đ Keywords
preeclampsia, maternal-fetal interface, non-compliant balloon angioplasty, circular R. N. A., therapeutic target, pulmonary embolism, sirtuin 1, small extracellular vesicles, high-risk pulmonary embolism, coronary artery compliance, coronary artery calcification, trophoblast, systemic thrombolysis, heart failure with preserved ejection fraction, clinical phenotype, obesity, mitofusin-2, visceral adipose tissue, intravascular lithotripsy, catheter-directed therapy, adipocyte-cardiomyocyte crosstalk, intravascular ultrasound, macrophage, pulmonary hypertension, circMFN2.
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