H. O. P. E. Extends Heart Transplant Window 03/24/26
Welcome to Cardiology Today â Recorded March 24, 2026. This episode summarizes 5 key cardiology studies on topics like residual pulmonary hypertension and heart transplantation. Key takeaway: H. O. P. E. Extends Heart Transplant Window.
Article Links:
Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. (European heart journal)
Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. (ESC heart failure)
Full episode page: https://podcast.explainheart.com/podcast/h-o-p-e-extends-heart-transplant-window-03-24-26/
đ Featured Articles
Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493330
Summary: The OPTION-STEMI trial found an ongoing clinical uncertainty regarding the optimal timing of complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease complicated by heart failure. This study established a direct comparison of immediate versus staged complete revascularization during the index admission. The trial’s design rigorously evaluated fractional flow reserve-guided complete revascularization for non-infarct-related arteries in this high-risk cohort.
Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871747
Summary: The study found that 24-hour hypothermic oxygenated perfusion (H. O. P. E.) successfully preserved graft viability in a porcine heart transplant model. This innovative approach extended preservation time up to 24 hours for both donation after circulatory death (D. C. D.) and donation after brain death (D. B. D.) donor hearts. H. O. P. E. demonstrated efficacy in mitigating organ injury, which is a known risk associated with prolonged standard static cold storage exceeding 4 to 5 hours.
Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871746
Summary: The U. K. CURATE registry revealed limited and conflicting evidence regarding the use of pulmonary hypertension (P. H.) medical therapy as a bridge to pulmonary endarterectomy (P. E. A.) for chronic thromboembolic pulmonary hypertension (C. T. E. P. H.). The study also demonstrated an absence of consensus on criteria for continuing or restarting P. H. medical therapy post-operatively. The registry provided crucial data on the characteristics and long-term outcomes of patients receiving P. H. bridging therapy, along with identifying characteristics of residual P. H. post-P. E. A.
Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871745
Summary: A multicenter cohort study involving 334 adult first-time lung transplant recipients established that pre-transplant Torque teno virus (T. T. V.) load is a significant factor in early post-transplant outcomes. This study demonstrated the relevance of T. T. V. levels, recognized as a surrogate marker of net immunosuppression, for lung transplantation patient care. The primary endpoint investigated was infection within 3 months, with plasma samples systematically collected immediately prior to transplantation.
Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41869902
Summary: The study found that a residual left atrial (L. A.) v wave predicts the clinical outcome following transcatheter edge-to-edge mitral valve repair (M-TEER). This investigation, involving 299 patients, demonstrated that monitoring L. A. pressure intraprocedurally effectively complements echocardiographic assessments of residual mitral regurgitation. The presence of a residual L. A. v wave provides crucial prognostic information for M-TEER success and patient outcomes.
đ Transcript
Today’s date is March 24, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. The OPTION-STEMI trial found an ongoing clinical uncertainty regarding the optimal timing of complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease complicated by heart failure. This study established a direct comparison of immediate versus staged complete revascularization during the index admission. The trial’s design rigorously evaluated fractional flow reserve-guided complete revascularization for non-infarct-related arteries in this high-risk cohort.
Article number two. Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. The study found that 24-hour hypothermic oxygenated perfusion (H. O. P. E.) successfully preserved graft viability in a porcine heart transplant model. This innovative approach extended preservation time up to 24 hours for both donation after circulatory death (D. C. D.) and donation after brain death (D. B. D.) donor hearts. H. O. P. E. demonstrated efficacy in mitigating organ injury, which is a known risk associated with prolonged standard static cold storage exceeding 4 to 5 hours.
Article number three. Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. The U. K. CURATE registry revealed limited and conflicting evidence regarding the use of pulmonary hypertension (P. H.) medical therapy as a bridge to pulmonary endarterectomy (P. E. A.) for chronic thromboembolic pulmonary hypertension (C. T. E. P. H.). The study also demonstrated an absence of consensus on criteria for continuing or restarting P. H. medical therapy post-operatively. The registry provided crucial data on the characteristics and long-term outcomes of patients receiving P. H. bridging therapy, along with identifying characteristics of residual P. H. post-P. E. A.
Article number four. Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. A multicenter cohort study involving 334 adult first-time lung transplant recipients established that pre-transplant Torque teno virus (T. T. V.) load is a significant factor in early post-transplant outcomes. This study demonstrated the relevance of T. T. V. levels, recognized as a surrogate marker of net immunosuppression, for lung transplantation patient care. The primary endpoint investigated was infection within 3 months, with plasma samples systematically collected immediately prior to transplantation.
Article number five. Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. The study found that a residual left atrial (L. A.) v wave predicts the clinical outcome following transcatheter edge-to-edge mitral valve repair (M-TEER). This investigation, involving 299 patients, demonstrated that monitoring L. A. pressure intraprocedurally effectively complements echocardiographic assessments of residual mitral regurgitation. The presence of a residual L. A. v wave provides crucial prognostic information for M-TEER success and patient outcomes.
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đ Keywords
residual pulmonary hypertension, heart transplantation, graft viability, post-transplant infection, multivessel disease, chronic thromboembolic pulmonary hypertension, Left atrial pressure, fractional flow reserve, transcatheter edge-to-edge mitral valve repair, cold ischemic time, mitral regurgitation, ST-segment elevation myocardial infarction, Hypothermic oxygenated perfusion, lung transplantation, v wave, prognostic indicator, pulmonary hypertension medical therapy, bridging therapy, Pulmonary endarterectomy, immunosuppression, complete revascularization, donation after circulatory death, Torque teno virus, heart failure, cohort study.
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