H. I. V. Donor Hearts Safely Used in Transplant. 03/01/26
Welcome to Cardiology Today â Recorded March 01, 2026. This episode summarizes 5 key cardiology studies on topics like Organ transplantation outcomes and Warm ischemia. Key takeaway: H. I. V. Donor Hearts Safely Used in Transplant..
Article Links:
Article 1: Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 2: Early experience in heart transplantation utilizing donors with HIV. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 3: Cardiac function recovery after 20-min hands-off using thoracoabdominal-normothermic regional perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 4: The Time is Upon Us-The Beginning of the End of Donor Heart Reanimation In Donation After Circulatory Death Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
Article 5: Improved DCD Heart Transplant Function Through Ferroptosis Blockade in a Model of Experimental Normothermic Ex Vivo Perfusion. (Transplantation)
Full episode page: https://podcast.explainheart.com/podcast/h-i-v-donor-hearts-safely-used-in-transplant-03-01-26/
đ Featured Articles
Article 1: Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297731
Summary: Females who undergo heart transplantation exhibit a reduced risk for cardiac allograft vasculopathy. This study found sex-biased immune rewiring as a potential underlying mechanism contributing to this differential risk. Understanding these sex-specific molecular patterns provides insight for improved risk stratification and precision immunosuppressive strategies in both adult and pediatric transplant recipients. This suggests sex-specific immunologic outcomes are significant after heart transplantation.
Article 2: Early experience in heart transplantation utilizing donors with HIV.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40998274
Summary: I. V. A single-center observational study investigated early outcomes of heart transplantation in 10 H. I. V.-positive recipients. Of these, 4 received organs from Human Immunodeficiency Virus positive donors and 6 from H. I. V.-negative donors. At 6 months, survival rates were similar, with 100 percent for recipients of H. I. V.-positive organs and 83 percent for recipients of H. I. V.-negative organs. Crucially, the study reported no Human Immunodeficiency Virus transmission from H. I. V.-positive donors to their recipients.
Article 3: Cardiac function recovery after 20-min hands-off using thoracoabdominal-normothermic regional perfusion.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947079
Summary: An Italian center performed heart transplantation from donation after circulatory death, utilizing thoracoabdominal-normothermic regional perfusion. The study demonstrated successful cardiac function recovery in donor hearts. This recovery was achieved despite a 20-minute period of functional warm ischemia, a duration relevant to legal mandates for death declaration. The findings highlight the feasibility of this technique for expanding the donor pool while adhering to preservation concerns.
Article 4: The Time is Upon Us-The Beginning of the End of Donor Heart Reanimation In Donation After Circulatory Death Transplantation.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41763375
Summary: Donation after circulatory death heart transplantation has re-emerged as a transformative strategy to expand the donor pool. Contemporary techniques such as thoracoabdominal-normothermic regional perfusion and direct procurement and perfusion have enabled successful heart transplantation from donation after circulatory death. These methods effectively mitigate ischemic injury and demonstrate post-transplant allograft function. Critically, this function is achieved without requiring pre-transplant assessment of viability or reanimation, marking a significant shift in historical practice.
Article 5: Improved DCD Heart Transplant Function Through Ferroptosis Blockade in a Model of Experimental Normothermic Ex Vivo Perfusion.
Journal: Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41490396
Summary: Ferroptosis is identified as a key contributor to organ ischemia-reperfusion injury, a significant challenge in donation after circulatory death heart transplantation. In a rat heart transplantation model, treatment with Liproxstatin-1, a selective ferroptosis inhibitor, during normothermic ex vivo heart perfusion significantly suppressed this form of cell death. Post-transplant, hearts in the Liproxstatin-1 group demonstrated significantly improved left ventricular function and reduced histological evidence of myocardial injury compared to controls. This concrete finding establishes ferroptosis blockade with Liproxstatin-1 as a novel strategy to enhance donation after circulatory death heart viability and function.
đ Transcript
Today’s date is March 01, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation. Females who undergo heart transplantation exhibit a reduced risk for cardiac allograft vasculopathy. This study found sex-biased immune rewiring as a potential underlying mechanism contributing to this differential risk. Understanding these sex-specific molecular patterns provides insight for improved risk stratification and precision immunosuppressive strategies in both adult and pediatric transplant recipients. This suggests sex-specific immunologic outcomes are significant after heart transplantation.
Article number two. Early experience in heart transplantation utilizing donors with H. I. V. A single-center observational study investigated early outcomes of heart transplantation in 10 H. I. V.-positive recipients. Of these, 4 received organs from Human Immunodeficiency Virus positive donors and 6 from H. I. V.-negative donors. At 6 months, survival rates were similar, with 100 percent for recipients of H. I. V.-positive organs and 83 percent for recipients of H. I. V.-negative organs. Crucially, the study reported no Human Immunodeficiency Virus transmission from H. I. V.-positive donors to their recipients.
Article number three. Cardiac function recovery after 20-min hands-off using thoracoabdominal-normothermic regional perfusion. An Italian center performed heart transplantation from donation after circulatory death, utilizing thoracoabdominal-normothermic regional perfusion. The study demonstrated successful cardiac function recovery in donor hearts. This recovery was achieved despite a 20-minute period of functional warm ischemia, a duration relevant to legal mandates for death declaration. The findings highlight the feasibility of this technique for expanding the donor pool while adhering to preservation concerns.
Article number four. The Time is Upon Us-The Beginning of the End of Donor Heart Reanimation In Donation After Circulatory Death Transplantation. Donation after circulatory death heart transplantation has re-emerged as a transformative strategy to expand the donor pool. Contemporary techniques such as thoracoabdominal-normothermic regional perfusion and direct procurement and perfusion have enabled successful heart transplantation from donation after circulatory death. These methods effectively mitigate ischemic injury and demonstrate post-transplant allograft function. Critically, this function is achieved without requiring pre-transplant assessment of viability or reanimation, marking a significant shift in historical practice.
Article number five. Improved DCD Heart Transplant Function Through Ferroptosis Blockade in a Model of Experimental Normothermic Ex Vivo Perfusion. Ferroptosis is identified as a key contributor to organ ischemia-reperfusion injury, a significant challenge in donation after circulatory death heart transplantation. In a rat heart transplantation model, treatment with Liproxstatin-1, a selective ferroptosis inhibitor, during normothermic ex vivo heart perfusion significantly suppressed this form of cell death. Post-transplant, hearts in the Liproxstatin-1 group demonstrated significantly improved left ventricular function and reduced histological evidence of myocardial injury compared to controls. This concrete finding establishes ferroptosis blockade with Liproxstatin-1 as a novel strategy to enhance donation after circulatory death heart viability and function.
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đ Keywords
Organ transplantation outcomes, Warm ischemia, Immune rewiring, Thoracoabdominal-Normothermic Regional Perfusion, Donation After Circulatory Death, Cardiac Allograft Vasculopathy, Sex-based differences, Liproxstatin-1, Immunosuppressive strategies, Ischemia-Reperfusion Injury, Direct Procurement and Perfusion, H. I. V. positive donors, Donation After Circulatory Death hearts, Ferroptosis, Allograft function, Human Immunodeficiency Virus, Heart Transplantation, Left ventricular function, H. I. V. positive recipients, Cardiac function recovery.
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