Tailored Antiplatelet Therapy Fails in CHIP PCI 09/01/25
Welcome to Cardiology Today – Episode recorded on September 01, 2025. Your source for the latest cardiology research findings from top medical journals.
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đ Episode Summary
This episode covers 1 recent cardiology research articles published in leading journals including NEJM, JACC, Circulation, European Heart Journal, and Nature Reviews Cardiology.
đ Featured Research Articles
Article 1: Temporal modulation of antiplatelet therapy in high-risk patients undergoing complex percutaneous coronary intervention: the TAILORED-CHIP randomized clinical trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40886179
Summary: The TAILORED-CHIP trial randomized over two thousand high-risk patients undergoing complex percutaneous coronary intervention to either a tailored antiplatelet strategy involving early escalation and later de-escalation of platelet inhibition based on platelet function testing, or a standard antiplatelet regimen. The study found that the tailored approach did not significantly reduce the composite endpoint of death, myocardial infarction, stroke, or major bleeding at one year compared to the standard strategy. These results suggest that routine platelet function testing to guide antiplatelet therapy after complex percutaneous coronary intervention may not offer superior outcomes in high-risk patients.
đ Full Episode Transcript
Today’s date is September 01, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Temporal modulation of antiplatelet therapy in high-risk patients undergoing complex percutaneous coronary intervention: the TAILORED-CHIP randomized clinical trial. The TAILORED-CHIP trial randomized over two thousand high-risk patients undergoing complex percutaneous coronary intervention to either a tailored antiplatelet strategy involving early escalation and later de-escalation of platelet inhibition based on platelet function testing, or a standard antiplatelet regimen. The study found that the tailored approach did not significantly reduce the composite endpoint of death, myocardial infarction, stroke, or major bleeding at one year compared to the standard strategy. These results suggest that routine platelet function testing to guide antiplatelet therapy after complex percutaneous coronary intervention may not offer superior outcomes in high-risk patients.
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đ Keywords
Medical Topics: Cardiology, Cardiovascular Medicine, Heart Disease, Clinical Research, Medical Education, Evidence-Based Medicine
Journals: New England Journal of Medicine (NEJM), Journal of American College of Cardiology (JACC), Circulation, European Heart Journal, Nature Reviews Cardiology
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Cardiology Today provides concise, professional summaries of cutting-edge cardiovascular research for healthcare professionals, medical students, and cardiology enthusiasts. Each episode features the latest findings from top-tier medical journals, delivered in an accessible format perfect for staying current with advances in cardiac care.
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