Xenotransplant: Genetic Editing for Success 02/18/26
Welcome to Cardiology Today â Recorded February 18, 2026. This episode summarizes 5 key cardiology studies on topics like congenitally corrected transposition of the great arteries and complex congenital heart disease. Key takeaway: Xenotransplant: Genetic Editing for Success.
Article Links:
Article 1: Arrhythmias in congenitally corrected transposition of the great arteries: an international study. (European heart journal)
Article 2: Catheter ablation in congenital heart diseases: a French nationwide study. (European heart journal)
Article 3: Residual lipid risk in atherosclerotic cardiovascular disease. (European heart journal)
Article 4: Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. (Transplantation)
Article 5: Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines. (International journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/xenotransplant-genetic-editing-for-success-02-18-26/
đ Featured Articles
Article 1: Arrhythmias in congenitally corrected transposition of the great arteries: an international study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40679844
Summary: An international multicenter retrospective cohort study quantified the incidence of atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block in patients with congenitally corrected transposition of the great arteries. This extensive study, conducted across 29 tertiary hospitals in six countries, identified factors associated with these significant cardiac rhythm disturbances. The research found specific prevalence rates for atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block within this complex patient population. These findings provide definitive data on the arrhythmia burden and associated risk factors for improved clinical management.
Article 2: Catheter ablation in congenital heart diseases: a French nationwide study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40396276
Summary: A French nationwide prospective study documented the outcomes of catheter ablation in patients with congenital heart disease across 28 centers from 2020 to 2024. The study found the per-procedural acute success rate for catheter ablation in this complex patient population. It also meticulously recorded associated complications and evaluated long-term freedom from arrhythmia recurrence. These comprehensive findings provide definitive national data on the effectiveness and safety of catheter ablation in congenital heart disease.
Article 3: Residual lipid risk in atherosclerotic cardiovascular disease.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41701506
Summary: Residual lipid risk persists in patients with or at risk of atherosclerotic cardiovascular disease, even after optimizing low-density lipoprotein cholesterol. Evidence highlights that non-low-density lipoprotein cholesterol fractions, including remnant cholesterol, lipoprotein(a), and apolipoprotein B, are key contributors to this residual risk. These non-low-density lipoprotein components definitively demonstrate their independent role in driving the progression of atherosclerotic cardiovascular disease. The identification of these persistent risk factors provides critical insights for developing therapeutic strategies beyond traditional low-density lipoprotein lowering.
Article 4: Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation.
Journal: Transplantation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41700849
Summary: The inaugural Richard Slayman Clinical Xenotransplantation Workshop, attended by over 140 international participants, identified significant advances and challenges in xenotransplantation. Discussions highlighted the increasing clinical readiness of kidney, heart, and liver xenotransplantation. Key findings from the workshop emphasized the crucial importance of meticulous patient selection and the pivotal role of genetic editing in reducing immune incompatibility. These consensuses establish current best practices and future directions for successfully translating xenotransplantation into wider clinical application.
Article 5: Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines.
Journal: International journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41702446
Summary: A study of 1033 Olympic-level athletes identified specific echocardiographic morpho-functional parameters that predict maximal oxygen uptake and oxygen pulse. The research established direct correlations between structural cardiac adaptations, commonly known as the athlete’s heart, and functional indices of cardiovascular performance. Results demonstrated how particular morphological changes observed via echocardiography are associated with enhanced cardiac efficiency during exertion. These findings provide measurable echocardiographic markers for assessing and monitoring cardiovascular performance and adaptive remodeling in elite athletes.
đ Transcript
Today’s date is February 18, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Arrhythmias in congenitally corrected transposition of the great arteries: an international study. An international multicenter retrospective cohort study quantified the incidence of atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block in patients with congenitally corrected transposition of the great arteries. This extensive study, conducted across 29 tertiary hospitals in six countries, identified factors associated with these significant cardiac rhythm disturbances. The research found specific prevalence rates for atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block within this complex patient population. These findings provide definitive data on the arrhythmia burden and associated risk factors for improved clinical management.
Article number two. Catheter ablation in congenital heart diseases: a French nationwide study. A French nationwide prospective study documented the outcomes of catheter ablation in patients with congenital heart disease across 28 centers from 2020 to 2024. The study found the per-procedural acute success rate for catheter ablation in this complex patient population. It also meticulously recorded associated complications and evaluated long-term freedom from arrhythmia recurrence. These comprehensive findings provide definitive national data on the effectiveness and safety of catheter ablation in congenital heart disease.
Article number three. Residual lipid risk in atherosclerotic cardiovascular disease. Residual lipid risk persists in patients with or at risk of atherosclerotic cardiovascular disease, even after optimizing low-density lipoprotein cholesterol. Evidence highlights that non-low-density lipoprotein cholesterol fractions, including remnant cholesterol, lipoprotein(a), and apolipoprotein B, are key contributors to this residual risk. These non-low-density lipoprotein components definitively demonstrate their independent role in driving the progression of atherosclerotic cardiovascular disease. The identification of these persistent risk factors provides critical insights for developing therapeutic strategies beyond traditional low-density lipoprotein lowering.
Article number four. Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. The inaugural Richard Slayman Clinical Xenotransplantation Workshop, attended by over 140 international participants, identified significant advances and challenges in xenotransplantation. Discussions highlighted the increasing clinical readiness of kidney, heart, and liver xenotransplantation. Key findings from the workshop emphasized the crucial importance of meticulous patient selection and the pivotal role of genetic editing in reducing immune incompatibility. These consensuses establish current best practices and future directions for successfully translating xenotransplantation into wider clinical application.
Article number five. Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines. A study of 1033 Olympic-level athletes identified specific echocardiographic morpho-functional parameters that predict maximal oxygen uptake and oxygen pulse. The research established direct correlations between structural cardiac adaptations, commonly known as the athlete’s heart, and functional indices of cardiovascular performance. Results demonstrated how particular morphological changes observed via echocardiography are associated with enhanced cardiac efficiency during exertion. These findings provide measurable echocardiographic markers for assessing and monitoring cardiovascular performance and adaptive remodeling in elite athletes.
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đ Keywords
congenitally corrected transposition of the great arteries, complex congenital heart disease, electrophysiology, per-procedural success, kidney xenotransplantation, heart xenotransplantation, complete atrioventricular block, arrhythmia recurrence, catheter ablation, atrial arrhythmia, atherosclerotic cardiovascular disease, maximal oxygen uptake, genetic editing, xenotransplantation, echocardiography, congenital heart disease, ventricular arrhythmia, lipoprotein(a), immune incompatibility, low-density lipoprotein cholesterol, athlete’s heart, remnant cholesterol, oxygen pulse, residual lipid risk, elite athletes.
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Concise summaries of cardiovascular research for professionals.
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