Histone Lactylation Aggravates Aortic Aneurysm 01/20/26
Welcome to Cardiology Today â Recorded January 20, 2026. This episode summarizes 5 key cardiology studies on topics like global mortality and global health. Key takeaway: Histone Lactylation Aggravates Aortic Aneurysm.
Article Links:
Article 1: Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation. (Journal of the American College of Cardiology)
Article 2: Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation. (Circulation)
Article 3: Environmental stressors and cardiovascular health: acting locally for global impact in a changing world. (European heart journal)
Article 4: Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon. (Journal of the American Heart Association)
Article 5: Clinical Impact of Switching From or Persisting With Rivaroxaban or Apixaban After a Bleeding Event: A Real-World Study in Patients With Nonvalvular Atrial Fibrillation. (Journal of the American Heart Association)
Full episode page: https://podcast.explainheart.com/podcast/histone-lactylation-aggravates-aortic-aneurysm-01-20-26/
đ Featured Articles
Article 1: Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation.
Journal: Journal of the American College of Cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41556866
Summary: A joint statement from leading cardiology organizations reported that non-communicable diseases account for 70 percent of global mortality, resulting in over 38 million deaths annually, with cardiovascular disease comprising most fatalities. The statement concluded that ubiquitous environmental risk factors significantly contribute to the genesis and rising prevalence of these diseases. This collective assessment underscores the critical impact of interconnected anthropogenic environmental stressors on cardiovascular health, requiring global and local action.
Article 2: Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41487086
Summary: This study found that histone lactylation mediates metabolic remodeling in vascular smooth muscle cells. This process aggravates aortic aneurysm and dissection by promoting lactate accumulation. Researchers observed this epigenetic regulation of histone lactylation in the aorta of patients with aortic aneurysm and in a murine model of aortic aneurysm and dissection.
Article 3: Environmental stressors and cardiovascular health: acting locally for global impact in a changing world.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41556518
Summary: This statement from major cardiology organizations reported that non-communicable diseases cause 70 percent of global mortality, leading to over 38 million deaths annually, with cardiovascular disease as the primary contributor. It concluded that ubiquitous environmental risk factors increasingly influence the genesis and rising prevalence of non-communicable diseases. The assessment underscores the profound impact of interconnected human-caused environmental stressors on cardiovascular health.
Article 4: Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41553092
Summary: This study established that caldesmon, an actomyosin-tropomyosin-binding protein inhibiting actomyosin adenosine triphosphatase activity, regulates vascular tone in the preglomerular renal vasculature. Researchers assessed the expression of caldesmon, myosin light chain, and alpha-smooth muscle actin in interlobar arteries from young and old mice. The study also analyzed human renal arteries from patients who underwent nephrectomy or tumor enucleation, providing further evidence for this regulatory mechanism.
Article 5: Clinical Impact of Switching From or Persisting With Rivaroxaban or Apixaban After a Bleeding Event: A Real-World Study in Patients With Nonvalvular Atrial Fibrillation.
Journal: Journal of the American Heart Association
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41553085
Summary: This real-world study characterized the clinical impact of changing or continuing direct oral anticoagulants after a bleeding event in patients with nonvalvular atrial fibrillation. The research specifically analyzed outcomes when patients switched from or persisted with rivaroxaban or apixaban. Researchers utilized United States claims data from Optum’s Clinformatics Data Mart Database to understand treatment decisions and subsequent patient outcomes in this population.
đ Transcript
Today’s date is January 20, 2026. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Environmental Stressors and Cardiovascular Health: Acting Locally for Global Impact in a Changing World: A statement of the European Society of Cardiology, the American College of Cardiology, the American Heart Association, and the World Heart Federation. A joint statement from leading cardiology organizations reported that non-communicable diseases account for 70 percent of global mortality, resulting in over 38 million deaths annually, with cardiovascular disease comprising most fatalities. The statement concluded that ubiquitous environmental risk factors significantly contribute to the genesis and rising prevalence of these diseases. This collective assessment underscores the critical impact of interconnected anthropogenic environmental stressors on cardiovascular health, requiring global and local action.
Article number two. Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation. This study found that histone lactylation mediates metabolic remodeling in vascular smooth muscle cells. This process aggravates aortic aneurysm and dissection by promoting lactate accumulation. Researchers observed this epigenetic regulation of histone lactylation in the aorta of patients with aortic aneurysm and in a murine model of aortic aneurysm and dissection.
Article number three. Environmental stressors and cardiovascular health: acting locally for global impact in a changing world. This statement from major cardiology organizations reported that non-communicable diseases cause 70 percent of global mortality, leading to over 38 million deaths annually, with cardiovascular disease as the primary contributor. It concluded that ubiquitous environmental risk factors increasingly influence the genesis and rising prevalence of non-communicable diseases. The assessment underscores the profound impact of interconnected human-caused environmental stressors on cardiovascular health.
Article number four. Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon. This study established that caldesmon, an actomyosin-tropomyosin-binding protein inhibiting actomyosin adenosine triphosphatase activity, regulates vascular tone in the preglomerular renal vasculature. Researchers assessed the expression of caldesmon, myosin light chain, and alpha-smooth muscle actin in interlobar arteries from young and old mice. The study also analyzed human renal arteries from patients who underwent nephrectomy or tumor enucleation, providing further evidence for this regulatory mechanism.
Article number five. Clinical Impact of Switching From or Persisting With Rivaroxaban or Apixaban After a Bleeding Event: A Real-World Study in Patients With Nonvalvular Atrial Fibrillation. This real-world study characterized the clinical impact of changing or continuing direct oral anticoagulants after a bleeding event in patients with nonvalvular atrial fibrillation. The research specifically analyzed outcomes when patients switched from or persisted with rivaroxaban or apixaban. Researchers utilized United States claims data from Optum’s Clinformatics Data Mart Database to understand treatment decisions and subsequent patient outcomes in this population.
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đ Keywords
global mortality, global health, direct oral anticoagulants, cardiovascular disease, vascular tone, environmental stressors, interlobar arteries, non-communicable diseases, rivaroxaban, aortic aneurysm, aortic dissection, bleeding events, caldesmon, nonvalvular atrial fibrillation, metabolic remodeling, anthropogenic factors, public health, environmental risk factors, preglomerular renal vasculature, apixaban, vascular smooth muscle cells, histone lactylation, adenosine triphosphatase.
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Concise summaries of cardiovascular research for professionals.
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