Targeting P2Y14R Prevents Venous Thrombosis 10/27/25
Welcome to Cardiology Today â Recorded October 27, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular outcomes and N.R.4.A.2. Key takeaway: Targeting P2Y14R Prevents Venous Thrombosis.
Article Links:
Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. (Circulation)
Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. (European heart journal)
Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. (Hypertension (Dallas, Tex. : 1979))
Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. (Hypertension (Dallas, Tex. : 1979))
Article 5: Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids. (JACC. Basic to translational science)
Full episode page: https://podcast.explainheart.com/podcast/targeting-p2y14r-prevents-venous-thrombosis-10-27-25/
đ Featured Articles
Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41139402
Summary: The A.N.D.E.S. Randomized Clinical Trial prospectively compared antithrombotic strategies after transcatheter left atrial appendage closure for patients with non-valvular atrial fibrillation. This multicenter international study randomized patients to either anticoagulation or dual antiplatelet therapy to determine the optimal approach for preventing device-related thrombosis. The trial’s objective was to establish which treatment strategy more effectively mitigates device-related thrombosis post-procedure. This research provides crucial evidence to guide clinical practice, potentially improving patient safety and outcomes following left atrial appendage closure.
Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41143464
Summary: This study investigated the role of the P2Y14 receptor, highly expressed on neutrophils, in venous thromboembolism. Researchers discovered that the P2Y14 receptor mediates neutrophil extracellular trap formation, which exacerbates thrombo-inflammatory responses and venous thromboembolism. Critically, targeting the P2Y14 receptor successfully alleviated platelet-induced neutrophil extracellular trap formation and venous thrombosis by modulating the P.K.A. / A.K.A.P.13 / R.h.o.A. axis. These findings establish the P2Y14 receptor as a promising therapeutic target for developing new strategies to combat venous thromboembolism.
Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140167
Summary: This study investigated the mechanisms driving aldosterone-producing cell cluster formation, which are frequently observed in primary aldosteronism. Researchers utilized an integrated analysis of spatial transcriptomics and single-cell ribonucleic acid sequencing on aldosterone-producing cell clusters, aldosterone-producing adenomas, and zona glomerulosa cells. The study aimed to elucidate the role of the stress-responsive N.R.4.A.2 gene in this process. Establishing a clearer understanding of these mechanisms provides a foundational basis for developing new diagnostic and therapeutic strategies for primary aldosteronism and related hypertension.
Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140152
Summary: This retrospective study analyzed the efficacy of the rice diet, a very low-sodium, low-protein, and low-fat regimen, in treating malignant hypertension from the 1940s. Researchers identified 544 malignant hypertension patients from 17487 historical charts to assess factors associated with blood pressure reduction, including dietary adherence. The study established that this strict dietary intervention effectively reduced blood pressure in a significant cohort of patients before modern antihypertensive drugs were available. This analysis highlights the profound impact of dietary modifications on managing severe hypertension and provides historical context for lifestyle-based blood pressure management.
Article 5: Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids.
Journal: JACC. Basic to translational science
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41139325
Summary: This translational study demonstrated that sphingolipids are a critical component of estrogen signaling within the human microvascular endothelium. Researchers discovered that estrogen influences microvascular endothelial function through sex-specific regulation of sphingolipids, with stark differences related to both time and biological sex. The study provided evidence that chronic estrogen treatment can promote endothelial dysfunction in isolated human microvessels. These findings are crucial for understanding sex differences in cardiovascular disease and developing targeted therapies by elucidating precise mechanisms of estrogen’s microvascular impact.
đ Transcript
Today’s date is October 27, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. The A.N.D.E.S. Randomized Clinical Trial prospectively compared antithrombotic strategies after transcatheter left atrial appendage closure for patients with non-valvular atrial fibrillation. This multicenter international study randomized patients to either anticoagulation or dual antiplatelet therapy to determine the optimal approach for preventing device-related thrombosis. The trial’s objective was to establish which treatment strategy more effectively mitigates device-related thrombosis post-procedure. This research provides crucial evidence to guide clinical practice, potentially improving patient safety and outcomes following left atrial appendage closure.
Article number two. Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. This study investigated the role of the P2Y14 receptor, highly expressed on neutrophils, in venous thromboembolism. Researchers discovered that the P2Y14 receptor mediates neutrophil extracellular trap formation, which exacerbates thrombo-inflammatory responses and venous thromboembolism. Critically, targeting the P2Y14 receptor successfully alleviated platelet-induced neutrophil extracellular trap formation and venous thrombosis by modulating the P.K.A. / A.K.A.P.13 / R.h.o.A. axis. These findings establish the P2Y14 receptor as a promising therapeutic target for developing new strategies to combat venous thromboembolism.
Article number three. Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. This study investigated the mechanisms driving aldosterone-producing cell cluster formation, which are frequently observed in primary aldosteronism. Researchers utilized an integrated analysis of spatial transcriptomics and single-cell ribonucleic acid sequencing on aldosterone-producing cell clusters, aldosterone-producing adenomas, and zona glomerulosa cells. The study aimed to elucidate the role of the stress-responsive N.R.4.A.2 gene in this process. Establishing a clearer understanding of these mechanisms provides a foundational basis for developing new diagnostic and therapeutic strategies for primary aldosteronism and related hypertension.
Article number four. Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. This retrospective study analyzed the efficacy of the rice diet, a very low-sodium, low-protein, and low-fat regimen, in treating malignant hypertension from the 1940s. Researchers identified 544 malignant hypertension patients from 17487 historical charts to assess factors associated with blood pressure reduction, including dietary adherence. The study established that this strict dietary intervention effectively reduced blood pressure in a significant cohort of patients before modern antihypertensive drugs were available. This analysis highlights the profound impact of dietary modifications on managing severe hypertension and provides historical context for lifestyle-based blood pressure management.
Article number five. Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids. This translational study demonstrated that sphingolipids are a critical component of estrogen signaling within the human microvascular endothelium. Researchers discovered that estrogen influences microvascular endothelial function through sex-specific regulation of sphingolipids, with stark differences related to both time and biological sex. The study provided evidence that chronic estrogen treatment can promote endothelial dysfunction in isolated human microvessels. These findings are crucial for understanding sex differences in cardiovascular disease and developing targeted therapies by elucidating precise mechanisms of estrogen’s microvascular impact.
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đ Keywords
cardiovascular outcomes, N.R.4.A.2, sphingolipids, sex-specific regulation, venous thromboembolism, antiplatelet therapy, malignant hypertension, P2Y14 receptor, single-cell ribonucleic acid sequencing, P.K.A. / A.K.A.P.13 / R.h.o.A. axis, device-related thrombosis, non-valvular atrial fibrillation, aldosterone-producing cell clusters, left atrial appendage closure, microvascular endothelial function, blood pressure reduction, spatial transcriptomics, dietary adherence, platelet-induced thrombosis, primary aldosteronism, low-sodium diet, estrogen, anticoagulation, rice diet, neutrophil extracellular trap.
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Concise summaries of cardiovascular research for professionals.
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