C.M.R. Strain Boosts H.C.M. Sudden Death Risk 10/12/25
Welcome to Cardiology Today â Recorded October 12, 2025. This episode summarizes 5 key cardiology studies on topics like Pulmonary disease and risk factors. Key takeaway: C.M.R. Strain Boosts H.C.M. Sudden Death Risk.
Article Links:
Article 1: Primary Graft Dysfunction in Patients Supported With Durable Left Ventricular Assist Devices Before Heart Transplantation. (JACC. Heart failure)
Article 2: Long-Term Outcomes in Women With a History of Peripartum Cardiomyopathy. (JACC. Heart failure)
Article 3: The association between polypharmacy and mortality in patients with heart failure: Results from the PULSE dataset. (ESC heart failure)
Article 4: Feature Tracking-Derived Global Longitudinal Strain Enhances Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy. (JACC. Cardiovascular imaging)
Article 5: Impact of Pulmonary Disease on Clinical Outcomes in Patients Undergoing Mitral Valve Edge-to-Edge Repair. (The American journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/c-m-r-strain-boosts-h-c-m-sudden-death-risk-10-12-25/
đ Featured Articles
Article 1: Primary Graft Dysfunction in Patients Supported With Durable Left Ventricular Assist Devices Before Heart Transplantation.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41074902
Summary: This study leveraged data from the International Consortium on Primary Graft Dysfunction to quantify outcomes and identify clinical risk factors for severe primary graft dysfunction in patients with durable Left Ventricular Assist Device support prior to heart transplantation. Building upon previous single-center studies, it identified trends and specific risk factors. The findings from this large consortium study will likely improve risk stratification and management strategies for this high-risk patient population undergoing heart transplantation.
Article 2: Long-Term Outcomes in Women With a History of Peripartum Cardiomyopathy.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41074900
Summary: This prospective study followed 96 women with peripartum cardiomyopathy for at least three years, providing crucial long-term outcome data which has previously been limited. Researchers evaluated the clinical course and echocardiographic parameters in these patients, who were diagnosed at a mean age of 31.6 years. The findings offer valuable insights into the prognosis and long-term management of peripartum cardiomyopathy, informing care strategies for affected women.
Article 3: The association between polypharmacy and mortality in patients with heart failure: Results from the PULSE dataset.
Journal: ESC heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41074682
Summary: dataset. This retrospective observational cohort study utilized the P.U.L.S.E. dataset to investigate the association between polypharmacy and mortality in patients hospitalized for heart failure. Analyzing medication data from admission and discharge, researchers employed Cox proportional hazard models to explore this relationship. The study’s findings reveal a significant association between polypharmacy and mortality, underscoring the importance of medication review and optimization in this vulnerable patient population.
Article 4: Feature Tracking-Derived Global Longitudinal Strain Enhances Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
Journal: JACC. Cardiovascular imaging
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41074892
Summary: This study demonstrated that Left Ventricular Global Longitudinal Strain, derived from Cardiac Magnetic Resonance feature tracking, significantly enhances risk stratification for sudden cardiac death in patients with hypertrophic cardiomyopathy. This marker provides incremental prognostic value beyond established European Society of Cardiology and American College of Cardiology/American Heart Association guidelines. The findings suggest that incorporating Left Ventricular Global Longitudinal Strain assessment could lead to more precise identification of high-risk patients, guiding more targeted interventions and improving clinical outcomes.
Article 5: Impact of Pulmonary Disease on Clinical Outcomes in Patients Undergoing Mitral Valve Edge-to-Edge Repair.
Journal: The American journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41075959
Summary: This study investigated the impact of pulmonary disease on clinical outcomes in 3,666 patients undergoing mitral transcatheter edge-to-edge repair, stratifying them by the presence or absence of pulmonary disease. The findings indicate that co-existing pulmonary disease significantly influences all-cause mortality following the procedure, as evaluated using Kaplan-Meier analysis. This highlights the importance of comprehensive pre-procedural assessment and risk stratification, potentially guiding patient selection and management strategies for mitral transcatheter edge-to-edge repair in this complex patient population.
đ Transcript
Today’s date is October 12, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Primary Graft Dysfunction in Patients Supported With Durable Left Ventricular Assist Devices Before Heart Transplantation. This study leveraged data from the International Consortium on Primary Graft Dysfunction to quantify outcomes and identify clinical risk factors for severe primary graft dysfunction in patients with durable Left Ventricular Assist Device support prior to heart transplantation. Building upon previous single-center studies, it identified trends and specific risk factors. The findings from this large consortium study will likely improve risk stratification and management strategies for this high-risk patient population undergoing heart transplantation.
Article number two. Long-Term Outcomes in Women With a History of Peripartum Cardiomyopathy. This prospective study followed 96 women with peripartum cardiomyopathy for at least three years, providing crucial long-term outcome data which has previously been limited. Researchers evaluated the clinical course and echocardiographic parameters in these patients, who were diagnosed at a mean age of 31.6 years. The findings offer valuable insights into the prognosis and long-term management of peripartum cardiomyopathy, informing care strategies for affected women.
Article number three. The association between polypharmacy and mortality in patients with heart failure: Results from the P.U.L.S.E. dataset. This retrospective observational cohort study utilized the P.U.L.S.E. dataset to investigate the association between polypharmacy and mortality in patients hospitalized for heart failure. Analyzing medication data from admission and discharge, researchers employed Cox proportional hazard models to explore this relationship. The study’s findings reveal a significant association between polypharmacy and mortality, underscoring the importance of medication review and optimization in this vulnerable patient population.
Article number four. Feature Tracking-Derived Global Longitudinal Strain Enhances Risk Stratification for Sudden Cardiac Death in Hypertrophic Cardiomyopathy. This study demonstrated that Left Ventricular Global Longitudinal Strain, derived from Cardiac Magnetic Resonance feature tracking, significantly enhances risk stratification for sudden cardiac death in patients with hypertrophic cardiomyopathy. This marker provides incremental prognostic value beyond established European Society of Cardiology and American College of Cardiology/American Heart Association guidelines. The findings suggest that incorporating Left Ventricular Global Longitudinal Strain assessment could lead to more precise identification of high-risk patients, guiding more targeted interventions and improving clinical outcomes.
Article number five. Impact of Pulmonary Disease on Clinical Outcomes in Patients Undergoing Mitral Valve Edge-to-Edge Repair. This study investigated the impact of pulmonary disease on clinical outcomes in 3,666 patients undergoing mitral transcatheter edge-to-edge repair, stratifying them by the presence or absence of pulmonary disease. The findings indicate that co-existing pulmonary disease significantly influences all-cause mortality following the procedure, as evaluated using Kaplan-Meier analysis. This highlights the importance of comprehensive pre-procedural assessment and risk stratification, potentially guiding patient selection and management strategies for mitral transcatheter edge-to-edge repair in this complex patient population.
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đ Keywords
Pulmonary disease, risk factors, Primary graft dysfunction, Global Longitudinal Strain, mitral regurgitation, Peripartum cardiomyopathy, risk stratification, Hypertrophic Cardiomyopathy, clinical outcomes, Left Ventricular Assist Device, long-term outcomes, heart transplantation, Cardiac Magnetic Resonance, Polypharmacy, Left Ventricular Ejection Fraction, heart failure, medication management, prognosis, post-transplant complications, P.U.L.S.E. dataset, Mitral Transcatheter Edge-to-Edge Repair, Sudden Cardiac Death, women’s heart health, mortality.
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Concise summaries of cardiovascular research for professionals.
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