Clonal Hematopoiesis Links to CAD Mortality 09/04/25
Welcome to Cardiology Today â Recorded September 04, 2025. This episode summarizes 5 key cardiology studies on topics like gestational hypertension and Mendelian randomization. Key takeaway: Clonal Hematopoiesis Links to CAD Mortality.
Article Links:
Article 1: Clinical care of family members of patients with dilated cardiomyopathy. (European heart journal)
Article 2: Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. (European heart journal)
Article 3: Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial. (European heart journal)
Article 4: Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease. (European heart journal)
Article 5: Sexual minority populations and disparities in cardiovascular healthcare. (European heart journal)
Full episode page: https://podcast.explainheart.com/podcast/clonal-hematopoiesis-links-to-cad-mortality-09-04-25/
đ Featured Articles
Article 1: Clinical care of family members of patients with dilated cardiomyopathy.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40902100
Summary: This consensus statement emphasizes tailoring cardiac screening regimens for family members of individuals with dilated cardiomyopathy based on both genetic and clinical information. It highlights the importance of genetic family screening after identifying a pathogenic variant in a proband, and recommends cardiac screening for all first-degree relatives. The approach advocates for individualized risk assessment at both individual and familial levels to optimize screening strategies.
Article 2: Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40900121
Summary: This genetic epidemiology study used Mendelian randomization to investigate the causal relationship between hypertensive disorders of pregnancy and later cardiovascular disease risk. Analyzing data from FinnGen and other consortia, the study aimed to determine if the observed associations between preeclampsia, gestational hypertension and cardiovascular outcomes reflect true causal pathways. These results could inform targeted prevention strategies for women with a history of hypertensive pregnancies.
Article 3: Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40900118
Summary: This analysis of the DEDICATE-DZHK6 trial examines sex-specific outcomes in patients with aortic stenosis undergoing transcatheter aortic valve implantation or surgical aortic valve replacement. While the main trial demonstrated non-inferiority of transcatheter aortic valve implantation compared to surgery, this pre-defined descriptive analysis focuses on differences in outcomes between men and women. Understanding these sex-specific nuances can help refine treatment strategies for aortic stenosis.
Article 4: Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40900105
Summary: This study investigated the link between clonal haematopoiesis of indeterminate potential and all-cause mortality in patients with angiographically confirmed coronary artery disease. Through deep sequencing of genes associated with clonal haematopoiesis of indeterminate potential in over 8,600 patients, the research identifies the prognostic relevance and explores the mechanisms by which clonal haematopoiesis of indeterminate potential, particularly TET2 mutations, impacts mortality in coronary artery disease. The findings may refine risk stratification and treatment strategies in patients with coronary artery disease.
Article 5: Sexual minority populations and disparities in cardiovascular healthcare.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40900101
Summary: This review highlights the increased risk of cardiovascular disease among sexual minority populations compared to heterosexual individuals, emphasizing the influence of minority stressors on cardiovascular health. It discusses the minority stress model, which posits that stressors across multiple levels contribute to cardiovascular disease risk in lesbian, gay, bisexual, queer, and other non-heterosexual people. Addressing these disparities requires understanding and mitigating minority stressors within the healthcare system.
đ Transcript
Today’s date is September 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Clinical care of family members of patients with dilated cardiomyopathy. This consensus statement emphasizes tailoring cardiac screening regimens for family members of individuals with dilated cardiomyopathy based on both genetic and clinical information. It highlights the importance of genetic family screening after identifying a pathogenic variant in a proband, and recommends cardiac screening for all first-degree relatives. The approach advocates for individualized risk assessment at both individual and familial levels to optimize screening strategies.
Article number two. Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. This genetic epidemiology study used Mendelian randomization to investigate the causal relationship between hypertensive disorders of pregnancy and later cardiovascular disease risk. Analyzing data from FinnGen and other consortia, the study aimed to determine if the observed associations between preeclampsia, gestational hypertension and cardiovascular outcomes reflect true causal pathways. These results could inform targeted prevention strategies for women with a history of hypertensive pregnancies.
Article number three. Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial. This analysis of the DEDICATE-DZHK6 trial examines sex-specific outcomes in patients with aortic stenosis undergoing transcatheter aortic valve implantation or surgical aortic valve replacement. While the main trial demonstrated non-inferiority of transcatheter aortic valve implantation compared to surgery, this pre-defined descriptive analysis focuses on differences in outcomes between men and women. Understanding these sex-specific nuances can help refine treatment strategies for aortic stenosis.
Article number four. Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease. This study investigated the link between clonal haematopoiesis of indeterminate potential and all-cause mortality in patients with angiographically confirmed coronary artery disease. Through deep sequencing of genes associated with clonal haematopoiesis of indeterminate potential in over 8,600 patients, the research identifies the prognostic relevance and explores the mechanisms by which clonal haematopoiesis of indeterminate potential, particularly TET2 mutations, impacts mortality in coronary artery disease. The findings may refine risk stratification and treatment strategies in patients with coronary artery disease.
Article number five. Sexual minority populations and disparities in cardiovascular healthcare. This review highlights the increased risk of cardiovascular disease among sexual minority populations compared to heterosexual individuals, emphasizing the influence of minority stressors on cardiovascular health. It discusses the minority stress model, which posits that stressors across multiple levels contribute to cardiovascular disease risk in lesbian, gay, bisexual, queer, and other non-heterosexual people. Addressing these disparities requires understanding and mitigating minority stressors within the healthcare system.
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đ Keywords
gestational hypertension, Mendelian randomization, clonal haematopoiesis of indeterminate potential, dilated cardiomyopathy, preeclampsia, gay, queer, genetic screening, TET2 mutations, bisexual, surgical aortic valve replacement, family screening, aortic stenosis, transcatheter aortic valve implantation, sex-specific outcomes, genetic epidemiology, sexual minority, DEDICATE-DZHK6 trial, cardiovascular disease, coronary artery disease, pathogenic variants, health disparities, all-cause mortality, lesbian, cardiac risk, cardiovascular risk, minority stress.
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Concise summaries of cardiovascular research for professionals.
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